4-CHLORO-7-CHLOROSULFONYL-2,1,3-BENZOXADIAZOLE

Base Information

• Chemical Name: 4-CHLORO-7-CHLOROSULFONYL-2,1,3-BENZOXADIAZOLE
• CAS No.: 142246-48-8
• Molecular Formula: C₆H₂Cl₂N₂O₃S
• Molecular Weight: 253.065
• Hs Code.: 2934999090
• Mol file: 142246-48-8.mol

Synonyms:4-Benzofurazansulfonylchloride, 7-chloro-; 4-Chloro-7-chlorosulfonyl-2,1,3-benzoxadiazole;7-Chloro-2,1,3-benzoxadiazole-4-sulfonyl chloride;7-Chlorobenzo[1,2,5]oxadiazole-4-sulfonyl chloride; CBD-Cl

Chemical Property of 4-CHLORO-7-CHLOROSULFONYL-2,1,3-BENZOXADIAZOLE

Chemical Property:

• Vapor Pressure: 4.25E-05mmHg at 25°C
• Melting Point: 85.0 to 89.0 °C
• Boiling Point: 361.7°C at 760 mmHg
• PKA: -6.24±0.50(Predicted)
• Flash Point: 172.5°C
• PSA: 81.44000
• Density: 1.789g/cm³
• LogP: 2.88450

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Chloro-2,1,3-benzoxadiazole-4-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 36/37/39-45-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-7-CHLOROSULFONYL-2,1,3-BENZOXADIAZOLE

There total 1 articles about 4-CHLORO-7-CHLOROSULFONYL-2,1,3-BENZOXADIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-chloro-2,1,3-benzoxadiazole (7116-16-7) → 7-chlorobenzo[c][1,2,5]oxadiazole-4-sulfonic acid chloride (142246-48-8)

Guidance literature:

With chlorosulfonic acid; at 20 - 120 ℃; for 6.5h;

DOI:10.1016/j.bmcl.2020.127128

Reference yield: 81.6%

7-chlorobenzo[c][1,2,5]oxadiazole-4-sulfonic acid chloride (142246-48-8) + diethylamine (109-89-7) → 4-chloro-N,N-diethylsulfonylamino benzoxadiazole

Guidance literature:

With trimethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/acs.analchem.7b02649

Reference yield: 76.0%

7-chlorobenzo[c][1,2,5]oxadiazole-4-sulfonic acid chloride (142246-48-8) + 5-(3-aminophenyl)-1H-tetrazole (73732-51-1) → N-(3-(1H-tetrazol-5-yl)phenyl)-7-chlorobenzo[c][1,2,5]oxadiazole-4-sulfonamide (1365720-12-2)

Guidance literature:

With pyridine; In dichloromethane; at 25 ℃; for 14h; Inert atmosphere;

DOI:10.1002/open.201402027

upstream raw materials:

4-chloro-2,1,3-benzoxadiazole

Downstream raw materials:

N-(3-(1H-tetrazol-5-yl)phenyl)-7-chlorobenzo[c][1,2,5]oxadiazole-4-sulfonamide