(2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide

Base Information

Chemical Name:(2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide
CAS No.:680227-93-4
Molecular Formula:C₂₆H₂₁F₄N₃O₄S
Molecular Weight:547.53
Hs Code.:

Synonyms:(2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide

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Chemical Property of (2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide

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Technology Process of (2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide

There total 7 articles about (2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 680230-10-8
N-[(3,5-difluorophenyl)acetyl]-L-serine

: 2,3-cis-3-amino-2-(2,5-difluorophenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride

: 680227-93-4
(2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide

: (2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2S,3S)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 680230-00-6
methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2,5-difluorophenyl)prop-2-enoate

: 680227-93-4
(2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol / 96 h / 25 °C

2: toluene-4-sulfonic acid / xylenes / 2 h / Heating / reflux

3: hydrogen bromide / acetic acid / 1.17 h / 25 °C

4: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2.08 h / 0 °C

With 4-methyl-morpholine; hydrogen bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; toluene-4-sulfonic acid; In methanol; dichloromethane; acetic acid; xylenes;

Reference yield:

: 950224-79-0
methyl β-[(2-aminophenyl)thio]-N-[(benzyloxy)carbonyl]-2,5-difluorophenylalaninate

: 680227-93-4
(2S)-2-{[(3,5-difluorophenyl)acetyl]amino}-N-[(2R,3R)-2-(2,5-difluorophenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-3-hydroxypropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / xylenes / 2 h / Heating / reflux

2: hydrogen bromide / acetic acid / 1.17 h / 25 °C

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2.08 h / 0 °C

With 4-methyl-morpholine; hydrogen bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; toluene-4-sulfonic acid; In dichloromethane; acetic acid; xylenes;