Technology Process of N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)-5-(2-fluoroethoxy)benzylamine
There total 9 articles about N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)-5-(2-fluoroethoxy)benzylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; tin(II) chloride dihdyrate;
In
methanol;
at 0 - 20 ℃;
DOI:10.1002/jlcr.3046
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Reflux; Inert atmosphere
2.1: tetrahydrofuran / -70 - 20 °C
3.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
4.1: borane-THF / tetrahydrofuran / 3 h / Reflux
4.2: 16 h / 20 °C
5.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
5.2: 22 h / 130 °C
6.1: hydrogenchloride; tin(II) chloride dihdyrate / methanol / 0 - 20 °C
With
hydrogenchloride; thionyl chloride; borane-THF; tin(II) chloride dihdyrate; boron tribromide; caesium carbonate; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jlcr.3046
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
1.2: 3 h / 20 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 23 h / 130 °C
4.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Reflux; Inert atmosphere
5.1: tetrahydrofuran / -70 - 20 °C
6.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
7.1: borane-THF / tetrahydrofuran / 3 h / Reflux
7.2: 16 h / 20 °C
8.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
8.2: 22 h / 130 °C
9.1: hydrogenchloride; tin(II) chloride dihdyrate / methanol / 0 - 20 °C
With
hydrogenchloride; sodium tetrahydroborate; thionyl chloride; borane-THF; tin(II) chloride dihdyrate; boron tribromide; potassium carbonate; caesium carbonate; N,N-dimethyl-formamide; sodium nitrite;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
1.1: |Sandmeyer Reaction / 1.2: |Sandmeyer Reaction;
DOI:10.1002/jlcr.3046
