N-(CHLOROACETYL)-4-(TRIFLUOROMETHOXY)ANILINE

Base Information

• Chemical Name: N-(CHLOROACETYL)-4-(TRIFLUOROMETHOXY)ANILINE
• CAS No.: 161290-85-3
• Molecular Formula: C₉H₇ClF₃NO₂
• Molecular Weight: 253.608
• Hs Code.: 2921420090
• Mol file: 161290-85-3.mol

Synonyms:2-Chloro-N-(4-trifluoromethoxyphenyl)acetamide;

Chemical Property of N-(CHLOROACETYL)-4-(TRIFLUOROMETHOXY)ANILINE

Chemical Property:

• Vapor Pressure: 0.000164mmHg at 25°C
• Melting Point: 135-136°C
• Refractive Index: 1.514
• Boiling Point: 330.6 °C at 760 mmHg
• Flash Point: 153.8 °C
• PSA: 38.33000
• Density: 1.455 g/cm³
• LogP: 2.83550
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-[4-(trifluoromethoxy)phenyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(CHLOROACETYL)-4-(TRIFLUOROMETHOXY)ANILINE

There total 2 articles about N-(CHLOROACETYL)-4-(TRIFLUOROMETHOXY)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.79%

4-(trifluoromethoxy)aniline (461-82-5) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(4-(trifluoromethoxy)phenyl)acetamide (161290-85-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2013.08.041

Reference yield:

→ 2-chloro-N-(4-(trifluoromethoxy)phenyl)acetamide (161290-85-3)

Guidance literature:

Reference yield: 96.0%

2-chloro-N-(4-(trifluoromethoxy)phenyl)acetamide (161290-85-3) → 2-iodo-N-[4-(trifluoromethoxy)phenyl]acetamide

Guidance literature:

With sodium iodide; In acetone; at 20 - 56 ℃; for 17h;

DOI:10.1021/acsmedchemlett.0c00649

upstream raw materials:

4-(trifluoromethoxy)aniline

chloroacetyl chloride

Refernces

• 1、 -. "CASPASE 6 INHIBITORS AND USES THEREOF". Paragraph 0612; 0660-0662. . Retrieved 2021/05/29.
• 2、 Zhang, Yilin,Yan, Yong,Liang, Lufan,Jiefeng,Wang, Xuejun,Li, Li,Yang, Kewu. "Halogen-substituted triazolethioacetamides as a potent skeleton for the development of metallo-β-lactamase inhibitors". . . Retrieved 2019/04/03.