C₁₈H₁₇FO₃

Base Information

• Chemical Name: C₁₈H₁₇FO₃
• CAS No.: 1394823-60-9
• Molecular Formula: C₁₈H₁₇FO₃
• Molecular Weight: 300.33
• Mol file: 1394823-60-9.mol

Synonyms:C₁₈H₁₇FO₃

Chemical Property of C₁₈H₁₇FO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₈H₁₇FO₃

There total 1 articles about C₁₈H₁₇FO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(2-bromo-5-fluorophenyl)-1,3-dioxolane (773094-69-2) + 1-phenyl-propan-1-one (93-55-0) → C18H17FO3 (1394823-60-9)

Guidance literature:

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium t-butanolate; In tetrahydrofuran; at 70 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1073/pnas.1206532109

Reference yield: 89.0%

C18H17FO3 (1394823-60-9) → C16H12FN (1394824-24-8)

Guidance literature:

With ammonium chloride; In ethanol; water; at 90 ℃; for 24h;

DOI:10.1073/pnas.1206532109

Reference yield: 86.0%

C18H17FO3 (1394823-60-9) → C16H12FNO (1394824-51-1)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; water; at 90 ℃; for 2h;

DOI:10.1073/pnas.1206532109

upstream raw materials:

2-(2-bromo-5-fluorophenyl)-1,3-dioxolane

1-phenyl-propan-1-one

Downstream raw materials:

C₁₆H₁₂FN

C₁₆H₁₂FNO

Refernces

• 1、 Donohoe, Timothy J.,Pilgrim, Ben S.,Jones, Geraint R.,Bassuto, Jose A.. "Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones". experimental part. p. 11605 - 11608. Retrieved 2012/09/07.