Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester

Base Information

• Chemical Name: Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester
• CAS No.: 159763-34-5
• Molecular Formula: C₁₆H₁₈O₆
• Molecular Weight: 306.315
• Mol file: 159763-34-5.mol

Synonyms:Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester

Chemical Property of Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester

There total 1 articles about Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

hydrogen ethyl malonate (1071-46-1) + methyl 3-hydroxy-2-methylidene-3-phenylpropionate (18020-59-2) → Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester (159763-34-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; for 6h; Ambient temperature;

DOI:10.1016/S0040-4020(01)89311-X

Reference yield:

Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester (159763-34-5) → Malonic acid ethyl ester (Z)-2-methoxycarbonyl-3-phenyl-allyl ester + Malonic acid ethyl ester (E)-2-methoxycarbonyl-3-phenyl-allyl ester

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; for 0.5h; Yield given. Yields of byproduct given; Heating;

DOI:10.1016/S0040-4020(01)89311-X

Reference yield:

Malonic acid ethyl ester 2-methoxycarbonyl-1-phenyl-allyl ester (159763-34-5) → 2-Ethoxycarbonyl-4-[1-phenyl-meth-(E)-ylidene]-pentanedioic acid 5-methyl ester + 2-Ethoxycarbonyl-4-[1-phenyl-meth-(Z)-ylidene]-pentanedioic acid 5-methyl ester

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; Yield given. Yields of byproduct given. Title compound not separated from byproducts; a) -78 deg C, 3 h, b) RT, 1 h;

DOI:10.1080/00397919508010805

upstream raw materials:

hydrogen ethyl malonate

methyl 3-hydroxy-2-methylidene-3-phenylpropionate