1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)

Base Information

Chemical Name:1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)
CAS No.:113524-00-8
Molecular Formula:C₃₄H₄₀ClN₂O₅P
Molecular Weight:623.129
Hs Code.:

Synonyms:1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)

Chemical Property:

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Technology Process of 1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)

There total 12 articles about 1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 113523-97-0
1-oxo-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)

: 113524-00-8
1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

Reference yield:

: 56021-31-9
4-chloro-3,5-dihydroxytoluene

: 113524-00-8
1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)

Guidance literature:: Multi-step reaction with 11 steps

1: 86 percent / K₂CO₃ / butan-2-one / 5 h / Heating

2: 62 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 5 h / 0 °C

3: 85 percent / K₂CO₃ / butan-2-one / 5 h / Heating

4: 97 percent / N-bromosuccinimide / CCl₄ / 1.5 h / Heating; Irradiation

5: 98 percent / aq. AgNO₃ / 2-methoxy-ethanol / 0.5 h / Heating

6: 84 percent / tetrabutylammonium permanganate / pyridine / 16 h / 4 °C

7: 84 percent / AlCl₃ / chlorobenzene / 0.75 h / Heating

8: 79 percent / HCl / 4 h / Heating

9: 86 percent / K₂CO₃ / butan-2-one / 16 h / Heating

10: 84 percent / 1.) buthyl-lithium/hexane / tetrahydrofuran / 1.) -50 deg C, 3 h; 2.) -78 deg C, 2 h

11: 91 percent / NaBH₄ / methanol / 1 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; aluminium trichloride; tetra-n-butylammonium permanganate; hexane; potassium carbonate; silver nitrate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; dichloromethane; 2-methoxy-ethanol; chlorobenzene; butanone;

Reference yield:

: 27971-69-3
2‐chloro‐1,3‐dimethoxy‐5‐methyl benzene

: 113524-00-8
1-hydroxy-1-(2,3,5-tribenzyloxy-4-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide)

Guidance literature:: Multi-step reaction with 10 steps

1: 62 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 5 h / 0 °C

2: 85 percent / K₂CO₃ / butan-2-one / 5 h / Heating

3: 97 percent / N-bromosuccinimide / CCl₄ / 1.5 h / Heating; Irradiation

4: 98 percent / aq. AgNO₃ / 2-methoxy-ethanol / 0.5 h / Heating

5: 84 percent / tetrabutylammonium permanganate / pyridine / 16 h / 4 °C

6: 84 percent / AlCl₃ / chlorobenzene / 0.75 h / Heating

7: 79 percent / HCl / 4 h / Heating

8: 86 percent / K₂CO₃ / butan-2-one / 16 h / Heating

9: 84 percent / 1.) buthyl-lithium/hexane / tetrahydrofuran / 1.) -50 deg C, 3 h; 2.) -78 deg C, 2 h

10: 91 percent / NaBH₄ / methanol / 1 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; aluminium trichloride; tetra-n-butylammonium permanganate; hexane; potassium carbonate; silver nitrate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; methanol; tetrachloromethane; dichloromethane; 2-methoxy-ethanol; chlorobenzene; butanone;