(+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide

Base Information

Chemical Name:(+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide
CAS No.:1304540-32-6
Molecular Formula:C₁₆H₂₁NO₃
Molecular Weight:275.348
Hs Code.:

Synonyms:(+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide

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Technology Process of (+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide

There total 5 articles about (+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 625-38-7
but-3-enoic acid

: 1304540-30-4
N-{(1S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-O-methylhydroxylamine

: 1304540-32-6
(+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/ol200688d

Reference yield:

: 1304540-10-0
(+)-tert-butyl {(1S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}methoxycarbamate

: 1304540-32-6
(+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol200688d

Reference yield:

: (2E)-4-[(phenylmethyl)oxy]-2-buten-1-yl methyl carbonate

: 1304540-32-6
(+)-N-{(1'S)-1-[(benzyloxy)methyl]prop-2-en-1-yl}-N-methoxybut-3-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: [O,O’-((S)-1,1′-dinaphthyl-2,2′-diyl)-N,N′-di-(S,S)-1-(2-methoxyphenyl)ethylphosphoramidite]; dichlorobis(η4-dibenzo[a,e]cyclooctatetraene)diiridium(I); 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 h / 50 °C / Inert atmosphere

2: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

With dmap; dichlorobis(η4-dibenzo[a,e]cyclooctatetraene)diiridium(I); [O,O’-((S)-1,1′-dinaphthyl-2,2′-diyl)-N,N′-di-(S,S)-1-(2-methoxyphenyl)ethylphosphoramidite]; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol200688d