2-Morpholinophenol

Base Information

• Chemical Name: 2-Morpholinophenol
• CAS No.: 41536-44-1
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2934999090
• European Community (EC) Number: 803-844-5
• DSSTox Substance ID: DTXSID30383651
• Mol file: 41536-44-1.mol

Synonyms:2-morpholinophenol;41536-44-1;2-(Morpholin-4-yl)phenol;2-morpholin-4-ylphenol;2-(4-MORPHOLINO)PHENOL;Phenol, 2-(4-morpholinyl)-;2-(4-morpholinyl)phenol;2-morpholin-4-yl-phenol;2-(4-morpholinyl)-phenol;SCHEMBL33868;DTXSID30383651;AMY32877;2-(4-morpholino)phenol, AldrichCPR;MFCD00051674;AKOS006230428;PS-4559;SDCCGMLS-0066215.P001;AC-26510;FT-0608681;EN300-1839178;A825587

Chemical Property of 2-Morpholinophenol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 215 °C
• Refractive Index: 1.575
• Boiling Point: 315.571 °C at 760 mmHg
• Flash Point: 144.652 °C
• PSA: 32.70000
• Density: 1.186 g/cm³
• LogP: 1.29380
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

98%min ^*data from raw suppliers

2-Morpholinophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC=CC=C2O

Technology Process of 2-Morpholinophenol

There total 8 articles about 2-Morpholinophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.6%

N-(2-methoxyphenyl)morpholine (27347-13-3) → 2-(4-morpholinyl)-phenol (41536-44-1)

Guidance literature:

With boron tribromide; In dichloromethane; at -5 - 20 ℃; for 14h;

Reference yield: 30.0%

4-(benzoyloxy)morpholine (5765-65-1) + phenol (108-95-2,27073-41-2) → 2-(4-morpholinyl)-phenol (41536-44-1)

Guidance literature:

With copper diacetate; lithium tert-butoxide; In cyclohexane; at 60 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1002/ijch.201900171

Reference yield: 25.0%

N-(2-fluorophenyl)-morpholine → 2-(4-morpholinyl)-phenol (41536-44-1)

Guidance literature:

With water; Irradiation;

DOI:10.1039/b812372a

upstream raw materials:

3-oxa-1,5-dichloropentane

2-amino-phenol

morpholine

cyclohexanone

Downstream raw materials:

4-(2-oxiran-2-ylmethoxy-phenyl)-morpholine

t-butyl N-{5-[2-(morpholin-4-yl)phenoxy]-2-nitrophenyl}-N-methylcarbamate

N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(2-morpholinophenoxy)acetamide

ethyl 2-(2-morpholinophenoxy)acetate

Refernces

• 1、 -. "PRMT5 INHIBITORS AND USES THEREOF". Paragraph 0370-0371. . Retrieved 2019/04/05.
• 2、 -. "PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF". Paragraph 00319. . Retrieved 2014/07/08.