(S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Base Information

Chemical Name:(S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid
CAS No.:83816-96-0
Molecular Formula:C₂₈H₃₇N₅O₁₄
Molecular Weight:667.627
Hs Code.:

Synonyms:(S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

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Chemical Property of (S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

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Technology Process of (S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

There total 4 articles about (S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83816-94-8
(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-{(S)-4-benzyloxycarbonyl-4-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-butyrylamino}-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

: 83816-96-0
(S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; for 18h; under 760 Torr; Ambient temperature;
DOI:10.1021/jm00356a035

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 83816-96-0
(S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 1.) 0 deg C, 5 h, 2.) RT, 16 h

2: 96 percent / HCl (4.4 N) / dioxane / 0.75 h / 25 °C

3: 82 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 1.) 0 deg C, 5 h, 2.) RT, 16 h

4: H₂ / 5percent Pd/C / dioxane; methanol / 18 h / 760 Torr / Ambient temperature

With hydrogenchloride; diphenylphosphoranyl azide; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00356a035

Reference yield:

: 83816-92-6
(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

: 83816-96-0
(S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / HCl (4.4 N) / dioxane / 0.75 h / 25 °C

2: 82 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 1.) 0 deg C, 5 h, 2.) RT, 16 h

3: H₂ / 5percent Pd/C / dioxane; methanol / 18 h / 760 Torr / Ambient temperature

With hydrogenchloride; diphenylphosphoranyl azide; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00356a035