(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

Base Information

Chemical Name:(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester
CAS No.:83816-92-6
Molecular Formula:C₄₈H₅₅N₃O₁₂
Molecular Weight:865.978
Hs Code.:

(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

Synonyms:(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

Suppliers and Price of (S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

There total 1 articles about (S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 30924-93-7
Boc-Glu-OBn

: 83816-90-4
N-(L-γ-glutamyl)-L-glutamic acid tribenzyl ester p-toluenesulfonate

: 83816-92-6
(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; 1.) 0 deg C, 5 h, 2.) RT, 16 h;
DOI:10.1021/jm00356a035

Reference yield: 96.0%

: 83816-92-6
(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

: 83816-93-7
N--L-glutamic acid tetrabenzyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 0.75h;
DOI:10.1021/jm00356a035

Reference yield:

: 83816-92-6
(S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester

: 73610-81-8
N-methylamino>benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / HCl (4.4 N) / dioxane / 0.75 h / 25 °C

2: 82 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 1.) 0 deg C, 5 h, 2.) RT, 16 h

3: H₂ / 5percent Pd/C / dioxane; methanol / 18 h / 760 Torr / Ambient temperature

4: 78 percent / N,N-dimethyl-acetamide / 144 h / 25 °C

With hydrogenchloride; diphenylphosphoranyl azide; hydrogen; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm00356a035