(3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one

Base Information

Chemical Name:(3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one
CAS No.:130268-14-3
Molecular Formula:C₂₁H₃₁IO₅Si
Molecular Weight:518.464
Hs Code.:

Synonyms:(3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one

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Chemical Property of (3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one

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Technology Process of (3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one

There total 4 articles about (3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133568-75-9
(3aS,4S,6S,6aR)-4-Hydroxy-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 130268-14-3
(3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 30 ℃; for 12h; Yield given;
DOI:10.1039/P19900001824

Reference yield:

: 62158-44-5
(1S,5R)-6-hydroxymethyl-2-oxabicyclo[3.3.0]oct-6-en-3-one

: 130268-14-3
(3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 93.5 percent / Ph₃P, diethyl azodicarboxylate (DEAD) / CH₂Cl₂ / 3 h / 25 °C

2: 1) 30percent NaOH, 2) KI, I₂ / 1) 25 deg C, 10 h, 2) H₂O, 0 to 5 deg C, 60 h

3: imidazole / dimethylformamide / 12 h / 30 °C

With 1H-imidazole; sodium hydroxide; iodine; triphenylphosphine; potassium iodide; diethylazodicarboxylate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/P19900001824

Reference yield:

: 130268-13-2
(3aR,6aS)-4-(4-Methoxy-phenoxymethyl)-3,3a,6,6a-tetrahydro-cyclopenta[b]furan-2-one

: 130268-14-3
(3aS,4S,6S,6aR)-4-(tert-Butyl-dimethyl-silanyloxy)-6-iodo-6a-(4-methoxy-phenoxymethyl)-hexahydro-cyclopenta[b]furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 30percent NaOH, 2) KI, I₂ / 1) 25 deg C, 10 h, 2) H₂O, 0 to 5 deg C, 60 h

2: imidazole / dimethylformamide / 12 h / 30 °C

With 1H-imidazole; sodium hydroxide; iodine; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1039/P19900001824