3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid

Base Information

• Chemical Name: 3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid
• CAS No.: 1310679-90-3
• Molecular Formula: C₂₁H₁₇ClN₂O₆
• Molecular Weight: 428.829
• Mol file: 1310679-90-3.mol

Synonyms:3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid

Chemical Property of 3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid

There total 3 articles about 3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-[4-(3-chloro-1,4-dihydro-1,4-dioxonaphthalen-2-yloxy)-phenyl]-5,6-dihydro-5-methylpyrimidine-2,4(1H,3H)-dione (1310679-87-8) → 3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid (1310679-90-3)

Guidance literature:

1-[4-(3-chloro-1,4-dihydro-1,4-dioxonaphthalen-2-yloxy)-phenyl]-5,6-dihydro-5-methylpyrimidine-2,4(1H,3H)-dione; With sodium hydroxide; In water; at 20 ℃; Reflux;

With hydrogenchloride; In water; pH=1;

DOI:10.1007/s00706-011-0466-x

Reference yield:

2,3-Dichloro-1,4-naphthoquinone (117-80-6) → 3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid (1310679-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / dimethyl sulfoxide / 48 h / 20 °C

2.1: sodium hydroxide / water / 20 °C / Reflux

2.2: pH 1

With sodium carbonate; sodium hydroxide; In water; dimethyl sulfoxide;

DOI:10.1007/s00706-011-0466-x

Reference yield:

1-(4-hydroxyphenyl)-5-methyldihydrouracil (83809-76-1) → 3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid (1310679-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / dimethyl sulfoxide / 48 h / 20 °C

2.1: sodium hydroxide / water / 20 °C / Reflux

2.2: pH 1

With sodium carbonate; sodium hydroxide; In water; dimethyl sulfoxide;

DOI:10.1007/s00706-011-0466-x

upstream raw materials:

2,3-Dichloro-1,4-naphthoquinone

1-[4-(3-chloro-1,4-dihydro-1,4-dioxonaphthalen-2-yloxy)-phenyl]-5,6-dihydro-5-methylpyrimidine-2,4(1H,3H)-dione

1-(4-hydroxyphenyl)-5-methyldihydrouracil

Downstream raw materials:

3-chloro-2-hydroxy-naphthalene-1,4-dione