2-Chloro-3-hydroxy-1,4-naphthoquinone

Base Information

• Chemical Name: 2-Chloro-3-hydroxy-1,4-naphthoquinone
• CAS No.: 1526-73-4
• Molecular Formula: C10H5 Cl O3
• Molecular Weight: 208.601
• Hs Code.: 2914700090
• Mol file: 1526-73-4.mol

Synonyms:1,4-Naphthoquinone,2-chloro-3-hydroxy- (6CI,7CI,8CI); 2-Chloro-3-hydroxy-1,4-naphthalenedione;2-Chloro-3-hydroxy-1,4-naphthoquinone; 2-Hydroxy-3-chloro-1,4-naphthoquinone;2-Hydroxy-3-chloronaphthoquinone; 3-Chloro-2-hydroxy-1,4-naphthoquinone;3-Chlorolawsone; NSC 93074

Chemical Property of 2-Chloro-3-hydroxy-1,4-naphthoquinone

Chemical Property:

• Vapor Pressure: 1.55E-05mmHg at 25°C
• Melting Point: 216.5°C
• Refractive Index: 1.5470 (estimate)
• Boiling Point: 351.2°Cat760mmHg
• Flash Point: 166.2°C
• PSA: 54.37000
• Density: 1.56g/cm³
• LogP: 2.07400

Purity/Quality:

98%min ^*data from raw suppliers

2-CHLORO-3-HYDROXY-1,4-NAPHTHOQUINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-hydroxy-1,4-naphthoquinone

There total 54 articles about 2-Chloro-3-hydroxy-1,4-naphthoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-phenyliodonio-1,2,4-trioxo-1,2,3,4-tetrahydronaphthalenide (117560-06-2) → 3-chloro-2-hydroxy-naphthalene-1,4-dione (1526-73-4)

Guidance literature:

With hydrogenchloride; In ethanol; for 8h; Ambient temperature;

Reference yield: 91.0%

2,3-Dichloro-1,4-naphthoquinone (117-80-6) → 3-chloro-2-hydroxy-naphthalene-1,4-dione (1526-73-4)

Guidance literature:

With sodium hydroxide; for 1h; Heating;

DOI:10.1021/jm00158a002

Reference yield: 90.0%

3-[N-(aminocarbonyl)-N-[4-(3-chloro-1,4-dihydro-1,4-di-oxonaphthalen-2-yloxy)phenyl]amino]-2-methylpropanoic acid (1310679-90-3) → 3-chloro-2-hydroxy-naphthalene-1,4-dione (1526-73-4)

Guidance literature:

With hydrogenchloride; water; for 1.5h; Reflux;

DOI:10.1007/s00706-011-0466-x

upstream raw materials:

2,3-Dichloro-1,4-naphthoquinone

ethanol

2,2,3,4,4-pentachloro-1-oxo-1,2,3,4-tetrahydronaphthaline

3-chloro-1,2-naphthoquinone

Downstream raw materials:

phthalic anhydride

2-hydroxynaphtho-1,4-quinone

6-Chlor-benzophenazin-5-ol

1,2,3,4,5-Pentachloronaphthalene

Refernces

• 1、 Chaudhari, Dinkar,Gejji, Shridhar P.,Lande, Dipali N.,Chakravarty, Debamitra,Salunke-Gawali, Sunita. "Polymorphism in chloro derivatives of 1,4-naphthoquinone: Experiment and density functional theoretic investigations". . p. 281 - 293. Retrieved 2016.
• 2、 Choudhari, Dinkar,Lande, Dipali N.,Bagade, Aditi,Gejji, Shridhar P.,Chakravarty, Debamitra,Kodam, Kisan M.,Salunke-Gawali, Sunita. "Molecular structures and biological activities of (N)-n-alkylammonium 2-chloro-3-oxido-1,4-naphthoquinone salts". . p. 309 - 320. Retrieved 2017.
• 3、 Yang, Qing,Zhang, Yilin,Zeng, Wei,Duan, Zheng-Chao,Sang, Xinxin,Wang, Dawei. "Merrifield resin-supported quinone as an efficient biomimetic catalyst for metal-free, base-free, chemoselective synthesis of 2,4,6-trisubstituted pyridines". supporting information. p. 5683 - 5690. Retrieved 2019/10/22.