3,5-Dimethoxypyridine

Base Information

• Chemical Name: 3,5-Dimethoxypyridine
• CAS No.: 18677-48-0
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50355850
• Nikkaji Number: J1.672.745H
• Wikidata: Q72468477
• Mol file: 18677-48-0.mol

Synonyms:3,5-dimethoxypyridine;18677-48-0;Pyridine, 3,5-dimethoxy-;MFCD01646188;3,5-dimethoxy-pyridine;SCHEMBL744752;AMY8057;DTXSID50355850;AKOS006276183;AC-4325;CS-W001486;DS-15809;SY024780;BB 0257716;FT-0645955;EN300-101251;AC-907/34118062;Z1198157277

Chemical Property of 3,5-Dimethoxypyridine

Chemical Property:

• Appearance/Colour: Colorless to pale yellow oil
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.488
• Boiling Point: 225.615 °C at 760 mmHg
• PKA: 4.00±0.10(Predicted)
• Flash Point: 81.985 °C
• PSA: 31.35000
• Density: 1.065 g/cm³
• LogP: 1.09880
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 87.6

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dimethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CN=C1)OC
• Uses: 3,5-Dimethoxypyridine (cas# 18677-48-0) is a compound useful in organic synthesis.

Technology Process of 3,5-Dimethoxypyridine

There total 8 articles about 3,5-Dimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

sodium methylate (124-41-4) + 2,5-difluoropyridine (84476-99-3) → 3,5-dimethoxypyridine (18677-48-0)

Guidance literature:

With methanol; at 135 ℃; for 0.25h; microwave;

Reference yield: 60.0%

3,5-dichloropyridine (2457-47-8) + potassium methanolate (865-33-8) → 3,5-dimethoxypyridine (18677-48-0)

Guidance literature:

In N,N-dimethyl-formamide; at 72 ℃; for 16h;

DOI:10.1021/ja0168460

Reference yield: 60.0%

3,5-dichloropyridine (2457-47-8) + sodium methylate (124-41-4) → 3,5-dimethoxypyridine (18677-48-0)

Guidance literature:

In N,N-dimethyl-formamide; at 230 ℃; for 0.333333h; microwave irradiation;

DOI:10.1055/s-2005-872094

upstream raw materials:

3,5-dibromopyridine

sodium methylate

3,5-dichloropyridine

potassium methanolate

Downstream raw materials:

2-(3,5-dimethoxy-benzyl)-5-isobutoxy-3-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

3-hydroxy-5-methoxypyridin-4-carbaldehyde

3,5-dimethoxy-4-(4-methoxy-benzyloxy)-pyridine

benzyl 3-hydroxy-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate