2-(Pyridin-2-yloxy)acetic acid

Base Information

• Chemical Name: 2-(Pyridin-2-yloxy)acetic acid
• CAS No.: 58530-50-0
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20355847
• Nikkaji Number: J1.996.111G
• Wikidata: Q72504319
• Mol file: 58530-50-0.mol

Synonyms:2-(pyridin-2-yloxy)acetic acid;58530-50-0;(2-Pyridinyloxy)acetic acid;2-pyridin-2-yloxyacetic acid;Acetic acid, (2-pyridinyloxy)-;(pyridin-2-yloxy)acetic acid;pyridinyloxyacetic acid;AC-907/34118029;SCHEMBL176214;2-(pyridin-2-yloxy)aceticacid;DTXSID20355847;NLVYFXLILFDECX-UHFFFAOYSA-N;MFCD01646171;SC3951;AKOS000505914;AC-4327;CS-W005910;AS-54657;FT-0604649;S-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline;EN300-234908;F2147-1058;2-(Pyridin-2-yloxy)acetic acid 2,2,2-trifluoroacetic acid

Chemical Property of 2-(Pyridin-2-yloxy)acetic acid

Chemical Property:

• Vapor Pressure: 0.00145mmHg at 25°C
• Melting Point: 112-113 °C
• Refractive Index: 1.544
• Boiling Point: 283.8 °C at 760 mmHg
• PKA: 2.01±0.10(Predicted)
• Flash Point: 125.5 °C
• PSA: 90.52000
• Density: 1.3 g/cm³
• LogP: 3.08870
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 153.042593085
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

2-(Pyridin-2-yloxy)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)OCC(=O)O

Technology Process of 2-(Pyridin-2-yloxy)acetic acid

There total 6 articles about 2-(Pyridin-2-yloxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(pyridin-2-yloxy)acetic acid tert-butyl ester (280565-68-6) → 2-(pyridin-2-yloxy)acetic acid (58530-50-0)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; for 4h;

DOI:10.1021/ja037614z

Reference yield:

(pyridin-2-yloxy)acetic acid ethyl ester (90972-27-3) → 2-(pyridin-2-yloxy)acetic acid (58530-50-0)

Guidance literature:

With sodium hydroxide; water;

Reference yield:

2-hydroxypyridin (142-08-5) → 2-(pyridin-2-yloxy)acetic acid (58530-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / Ag₂CO₃ / toluene / Heating

2: 92 percent / trifluoroacetic acid; triethylsilane / CH₂Cl₂ / 4 h

With triethylsilane; silver carbonate; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1021/ja037614z

upstream raw materials:

(pyridin-2-yloxy)acetic acid ethyl ester

(pyridin-2-yloxy)acetic acid tert-butyl ester

2-hydroxypyridin

2-Pyridone

Refernces

• 1、 Al-Ghorbani,Rekha,Lakshmi Ranganatha,Prashanth,Veerabasappagowda,Khanum. "Synthesis and biological efficacy of novel piperazine analogues bearing quinoline and pyridine moieties". . p. 554 - 561. Retrieved 2015/10/12.