90972-27-3

Usage

InChI:InChI=1/C9H11NO3/c1-2-12-9(11)7-13-8-5-3-4-6-10-8/h3-6H,2,7H2,1H3

Upstream product

• 142-08-5 2-Pyridone 
• 623-73-4 diazoacetic acid ethyl ester 
• 109-04-6 2-bromo-pyridine 
• 38233-96-4 ethyl 2-hydroxyacetate sodium salt 
• 142-08-5 2-hydroxypyridin 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 58530-50-0 2-(pyridin-2-yloxy)acetic acid 

Relevant academic research and scientific papers

Synthesis, structure analysis, DFT calculations and energy frameworks of new coumarin appended oxadiazoles, to regress ascites malignancy by targeting VEGF mediated angiogenesis

Ascites malignancy is a frequent cause of morbidity and presents significant management problems which occur in many cancers. Angiogenesis plays a major role in the prognosis of ascites tumor through Vascular Endothelial Growth Factor (VEGF). Inhibition o

A class of 1, 3, 4 - oxadiazole thioether compound and its preparation method and application

The invention relates to a 1, 3, 4 - oxadiazole thioether compound and its preparation method and application. This compound has the general formula (I) indicated by the structure: This compound to the pathogenic pathogenic bacteria and fungi has better inhibition effect, against such as [...] Phaeosphaeria, tobacco wilt bacteria in, cucumber bacterial leaf spot pathogenic bacteria, konjak bacterial leaf spot pathogenic bacteria, for citrus ulcer bacteria, grape ulcer bacteria, for tomato ulcer germs, kiwi ulcer germs, bacteria apple ulcer, gray mold of cucumber, hot pepper blight pathogen, Sclerotinia sclerotiorum, rice sheath blight fungus, potato Phytophthora infestans, blueberries Pratylenchus bacteria and other have better suppression effect.

Design and synthesis of conjugated azo-hydrazone analogues using nano BF3·SiO2 targeting ROS homeostasis in oncogenic and vascular progression

Disrupted redox balance is implicated in multiple pathologies including malignant progression and tumor angiogenesis. In this investigation, we report the design and development of novel and effective ROS detoxifying azo-hydrazone molecules targeting mali

Synthesis and biological efficacy of novel piperazine analogues bearing quinoline and pyridine moieties

A series of novel piperazine analogues bearing quinolin-8-yloxy-butan-1-ones/pyridin-2-yloxyethanones were synthesized by a simple and convenient approach based on various substituted piperazine incorporating quinoline and pyridine moieties. The analogues were evaluated for in vitro antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferrous ion radical scavenging activities and anti-inflammatory activity by inhibition of Vipera russelli venom (PLA2) and gastric K+/H+-ATPase activities. Most of the title compounds exhibited promising activity. Best antioxidant and PLA2-inhibiting activities were found for piperazine analogues with phenyl and nitro phenyl groups, whereas methoxy group on phenyl piperazine indicated selectivity for the H+/K+-ATPase.

QUINOLINONE DERIVATIVES

The present invention relates to compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.

A Rhodium(II) catalytic approach to the synthesis of ethers of a minor component in a tautomeric set.

[equation--see text] The Rh(II)-catalyzed reaction of diazoacetic esters with various carbonyl compounds is an effective method for the synthesis of acetic ester ethers of the corresponding enol forms.