2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate

Base Information

Chemical Name:2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate
CAS No.:1415043-87-6
Molecular Formula:CH₄O₃S*C₂₇H₃₀FN₃O₅S
Molecular Weight:623.724
Hs Code.:

2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate

Synonyms:2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate

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Chemical Property of 2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate

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Technology Process of 2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate

There total 8 articles about 2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1415043-86-5
2-(Dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

: 1415043-87-6
2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate

Guidance literature:: In tetrahydrofuran;

Reference yield:

: 643763-14-8
2-[(4-fluorophenyl)sulfanyl]benzaldehyde

: 1415043-87-6
2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Cooling with acetone-dry ice

2: acetic anhydride; hypophosphorous acid; water; hydrogen iodide / 96 h / 20 °C

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 5 h / 20 °C

4: tetrahydrofuran

With dmap; water; hydrogen iodide; hypophosphorous acid; acetic anhydride; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

Reference yield:

: [3-(2,2-dimethyl-4,6-dioxo-[1,3]-dioxan-5-yl)-3-oxo-propyl]-carbamic acid tert-butyl ester

: 1415043-87-6
2-(dimethylamino)ethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1yl)acetate monomesylate

Guidance literature:: Multi-step reaction with 6 steps

1: ethyl acetate / 2.5 h / Reflux

2: potassium carbonate / chloroform / 20 °C

3: sodium acetate / ethanol / 20 °C

4: acetic anhydride; hypophosphorous acid; water; hydrogen iodide / 96 h / 20 °C

5: dmap; dicyclohexyl-carbodiimide / dichloromethane / 5 h / 20 °C

6: tetrahydrofuran

With dmap; water; hydrogen iodide; sodium acetate; hypophosphorous acid; acetic anhydride; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; ethyl acetate;