5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid

Base Information

• Chemical Name: 5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid
• CAS No.: 471242-55-4
• Molecular Formula: C₂₆H₃₆O₅Si
• Molecular Weight: 456.654
• Mol file: 471242-55-4.mol

Synonyms:5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid

Chemical Property of 5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid

There total 3 articles about 5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

glutaric anhydride, (108-55-4) + α,α,α-(4-t-butyldimethylsilyloxyphenyl)dimethyl-p-cresol (111983-33-6) → 5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid (471242-55-4)

Guidance literature:

With dmap; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jf0202739

Reference yield:

BPA (80-05-7) → 5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid (471242-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / imidazole / dimethylformamide / 1 h / 20 °C

2: 53 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jf0202739

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5-{4-[1-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1-methylethyl]phenoxy}-5-oxopentanoic acid (471242-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / imidazole / dimethylformamide / 1 h / 20 °C

2: 53 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jf0202739

upstream raw materials:

glutaric anhydride,

α,α,α-(4-t-butyldimethylsilyloxyphenyl)dimethyl-p-cresol

BPA

tert-butyldimethylsilyl chloride