(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid

Base Information

Chemical Name:(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid
CAS No.:1401872-01-2
Molecular Formula:C₃₁H₃₈O₄Si
Molecular Weight:502.726
Hs Code.:

Synonyms:(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid

Suppliers and Price of (4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid

There total 5 articles about (4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1401872-24-9
C₃₁H₃₈O₃Si

: 1401872-01-2
(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate dihydrate; In tert-butyl alcohol; at 0 - 20 ℃; for 2h;
DOI:10.1002/hlca.201200064

Reference yield:

: 1380510-77-9
C₁₉H₂₈O₄

: 1401872-01-2
(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 6 h / 20 °C / Inert atmosphere

2.1: acetic acid / water / 12 h / 20 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 4 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / methanol / 1 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide / tetrahydrofuran / 0.17 h / Inert atmosphere

5.2: 1 h / -20 °C / Inert atmosphere

6.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6.2: 12 h / 20 °C / Inert atmosphere

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere

8.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

9.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / tert-butyl alcohol / 2 h / 0 - 20 °C

With 1H-imidazole; sodium chlorite; copper(l) iodide; sodium dihydrogenphosphate dihydrate; oxalyl dichloride; water; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; 8.1: |Swern Oxidation;
DOI:10.1002/hlca.201200064

Reference yield:

: 1401872-16-9
(4R,5S)-5-(benzyloxy)-8-[(4-methoxybenzyl)oxy]oct-1-en-4-ol

: 1401872-01-2
(4S,5R)-4-(benzyloxy)-5-{[(tert-butyl)(diphenyl)silyl]oxy}oct-7-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / tert-butyl alcohol / 2 h / 0 - 20 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate dihydrate; oxalyl dichloride; water; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; tert-butyl alcohol; 3.1: |Swern Oxidation;
DOI:10.1002/hlca.201200064