2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide

Base Information

Chemical Name:2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide
CAS No.:1369762-46-8
Molecular Formula:C₁₆H₁₈F₃N₃O₂
Molecular Weight:341.333
Hs Code.:

Synonyms:2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide

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Chemical Property of 2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide

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Technology Process of 2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide

There total 3 articles about 2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1183381-25-0
2-amino-N-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethyl)acetamide

: 120-92-3
cyclopentanone

: 1369762-46-8
2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide

Guidance literature:: With triethylamine; In ethanol; for 20h; Molecular sieve; Reflux;
DOI:10.1021/ol300468g

Reference yield:

: 1369762-45-7
benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate

: 1369762-46-8
2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 2585.81 Torr

2: triethylamine / ethanol / 20 h / Molecular sieve; Reflux

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; ethanol;
DOI:10.1021/ol300468g

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1369762-46-8
2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: propylphosphonic anhydride; N-ethyl-N,N-diisopropylamine / dichloromethane; ethyl acetate / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 2585.81 Torr

3: triethylamine / ethanol / 20 h / Molecular sieve; Reflux

With palladium 10% on activated carbon; propylphosphonic anhydride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/ol300468g