benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate

Base Information

• Chemical Name: benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate
• CAS No.: 1369762-45-7
• Molecular Formula: C₁₉H₁₈F₃N₃O₄
• Molecular Weight: 409.365
• Mol file: 1369762-45-7.mol

Synonyms:benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate

Chemical Property of benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate

There total 1 articles about benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

CbzGlyGly (2566-19-0) + 3-trifluoromethylaniline (98-16-8) → benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate (1369762-45-7)

Guidance literature:

With propylphosphonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; at 20 ℃;

DOI:10.1021/ol300468g

Reference yield: 100.0%

benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate (1369762-45-7) → 2-amino-N-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethyl)acetamide (1183381-25-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 2585.81 Torr;

DOI:10.1021/ol300468g

Reference yield:

benzyl 2-oxo-2-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethylamino)ethylcarbamate (1369762-45-7) → 2-(4-(4-methyl-1H-imidazol-1-yl)phenyl)-3-oxo-4-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethyl)-1,4-diazaspiro[4.4]non-1-ene 1-oxide (1369762-48-0)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 2585.81 Torr

2: triethylamine / ethanol / 20 h / Molecular sieve; Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C

4: palladium diacetate; potassium carbonate; triphenylphosphine / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; palladium diacetate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; dichloromethane;

DOI:10.1021/ol300468g

upstream raw materials:

CbzGlyGly

3-trifluoromethylaniline

Downstream raw materials:

2-{3-[4-(4-methyl-1H-imidazol-1-yl)phenyl]-2-oxo-1,4-diazaspiro[4.4]non-3-en-1-yl}-N-[3-(trifluoromethyl)phenyl]acetamide

2-amino-N-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethyl)acetamide

2-(2-oxo-1,4-diazaspiro[4.4]nonan-1-yl)-N-(3-(trifluoromethyl)phenyl)acetamide

3-oxo-4-(2-oxo-2-(3-(trifluoromethyl)phenylamino)ethyl)-1,4-diazaspiro[4.4]non-1-ene 1-oxide

Refernces