5-(2-Aminoethyl)-4-bromo-2-methoxyphenol

Base Information

• Chemical Name: 5-(2-Aminoethyl)-4-bromo-2-methoxyphenol
• CAS No.: 56522-51-1
• Molecular Formula: C₉H₁₂BrNO₂
• Molecular Weight: 246.104
• DSSTox Substance ID: DTXSID101276839
• Nikkaji Number: J1.701.143J
• Mol file: 56522-51-1.mol

Synonyms:56522-51-1;5-(2-aminoethyl)-4-bromo-2-methoxyphenol;SCHEMBL5351939;DTXSID101276839;EN300-1894138

Chemical Property of 5-(2-Aminoethyl)-4-bromo-2-methoxyphenol

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 245.00514
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C(C(=C1)Br)CCN)O

Technology Process of 5-(2-Aminoethyl)-4-bromo-2-methoxyphenol

There total 10 articles about 5-(2-Aminoethyl)-4-bromo-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromo-5-hydroxy-4-methoxyphenylacetamide (862794-28-3) → 2-bromo-5-hydroxy-4-methoxyphenethylamine (56522-51-1)

Guidance literature:

With tetrahydrofuran; borane; In tetrahydrofuran; for 5h; Heating;

DOI:10.1016/j.tet.2005.05.055

Reference yield: 75.0%

2-bromo-5-hydroxy-4-methoxybenzeneacetaldehyde oxime (444575-78-4) → 2-bromo-5-hydroxy-4-methoxyphenethylamine (56522-51-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 48h; Heating;

DOI:10.1016/S0040-4020(01)01235-2

Reference yield: 61.0%

4-bromo-2-methoxy-5-(2-nitroethenyl)phenol (252186-55-3) → 2-bromo-5-hydroxy-4-methoxyphenethylamine (56522-51-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1016/S0040-4020(01)01235-2

upstream raw materials:

4-bromo-2-methoxy-5-(2-nitroethenyl)phenol

2-bromo-5-hydroxy-4-methoxybenzeneacetaldehyde oxime

2-bromo-5-hydroxy-4-methoxyphenylacetamide

homoisovanillic acid

Downstream raw materials:

1,2,3,4-tetrahydro-1-(3',4'-dihydroxybenzyl)-7-methoxy-N-methylisoquinolin-8-ol