(S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

Base Information

Chemical Name:(S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol
CAS No.:188400-43-3
Molecular Formula:C₁₇H₃₀O₄Si
Molecular Weight:326.508
Hs Code.:

Synonyms:(S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

Suppliers and Price of (S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

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Technology Process of (S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

There total 3 articles about (S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 109786-74-5
(R)-3-(4-methoxybenzyloxy)propane-1,2-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 188400-43-3
(S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 25 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jacs.9b06830

Reference yield:

: 109786-73-4
(S)-4-[(4-methoxybenzyloxy)methyl]-2,2-dimethyl-1,3-dioxolane

: 188400-43-3
(S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / water / 1 h / Inert atmosphere; Heating

2: 1H-imidazole / dichloromethane / 1 h / 0 - 25 °C / Inert atmosphere

With 1H-imidazole; acetic acid; In dichloromethane; water;
DOI:10.1021/jacs.9b06830

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 188400-43-3
(S)-1-((tert-butyldimethylsilyl)oxy)-3-((4-methoxybenzyl)oxy)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 25 °C / Inert atmosphere

1.2: 0 - 25 °C / Inert atmosphere

2.1: acetic acid / water / 1 h / Inert atmosphere; Heating

3.1: 1H-imidazole / dichloromethane / 1 h / 0 - 25 °C / Inert atmosphere

With 1H-imidazole; sodium hydride; acetic acid; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jacs.9b06830