2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid

Base Information

Chemical Name:2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid
CAS No.:1215118-62-9
Molecular Formula:C₂₃H₁₉F₆NO₃
Molecular Weight:471.399
Hs Code.:

Synonyms:2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid

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Chemical Property of 2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid

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Technology Process of 2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid

There total 17 articles about 2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: methyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

: 1215118-62-9
2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; at 50 ℃; for 2h;
DOI:10.1021/acs.joc.8b00229

Reference yield:

: 1215119-23-5
ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

: 1215118-62-9
2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid

Guidance literature:: ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate; With water; lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 8h;

With citric acid; In 1,4-dioxane; water; pH=4;

Reference yield:

: 1215119-18-8
ethyl 2-(benzyloxy)-9-hydroxy-6,7-dihydropyrido[1,2-a]indole-8-carboxylate

: 1215118-62-9
2-(2-(3,5-bis-(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; acetic acid / 0.17 h / 220 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

2.2: 2 h / 65 °C

3.1: ammonium formate / 20 wt% Pd(OH)2/C / tetrahydrofuran; methanol / 5 h / Reflux; Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 75 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 8 h / 20 °C

5.2: pH 4

With water; ammonium formate; sodium hydride; caesium carbonate; acetic acid; lithium hydroxide; 20 wt% Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;