ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

Base Information

Chemical Name:ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate
CAS No.:1215119-23-5
Molecular Formula:C₂₅H₂₃F₆NO₃
Molecular Weight:499.453
Hs Code.:

Synonyms:ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

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Chemical Property of ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

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Technology Process of ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

There total 8 articles about ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215119-07-5
ethyl 2-(2-hydroxy-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

: 32247-96-4
3,5-bis(trifluoromethyl)benzyl bromide

: 1215119-23-5
ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 15h;

Reference yield:

: 1215119-18-8
ethyl 2-(benzyloxy)-9-hydroxy-6,7-dihydropyrido[1,2-a]indole-8-carboxylate

: 1215119-23-5
ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; acetic acid / 0.17 h / 220 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

2.2: 2 h / 65 °C

3.1: ammonium formate / 20 wt% Pd(OH)2/C / tetrahydrofuran; methanol / 5 h / Reflux; Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 75 °C

With water; ammonium formate; sodium hydride; caesium carbonate; acetic acid; 20 wt% Pd(OH)2/C; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1215119-17-7
ethyl 5-(benzyloxy)-1-(4-ethoxy-4-oxobutyl)-1H-indole-2-carboxylate

: 1215119-23-5
ethyl 2-(2-(3,5-bis(trifluoromethyl)benzyloxy)-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C

2.1: water; acetic acid / 0.17 h / 220 °C / Microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

3.2: 2 h / 65 °C

4.1: ammonium formate / 20 wt% Pd(OH)2/C / tetrahydrofuran; methanol / 5 h / Reflux; Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 75 °C

With potassium tert-butylate; water; ammonium formate; sodium hydride; caesium carbonate; acetic acid; 20 wt% Pd(OH)2/C; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;