(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine

Base Information

Chemical Name:(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine
CAS No.:145439-99-2
Molecular Formula:C₂₅H₂₇ClN₄O₃Si
Molecular Weight:495.053
Hs Code.:

Synonyms:(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine

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Technology Process of (+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine

There total 2 articles about (+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87-42-3
6-chloropurine

: 145439-99-2
(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium sulfate / 2 h / Heating

2: TMSOTf / CH₂Cl₂ / a) RT, 30 min, b) reflux, 14 h

With ammonium sulfate; trimethylsilyl trifluoromethanesulfonate; In dichloromethane;
DOI:10.1021/jm00053a004

Reference yield:

: 32865-86-4
6-chloro-9-trimethylsilylpurine

: 229635-18-1
(2R)-4-acetoxy-2-<<(tert-butyldiphenylsilyl)oxy>methyl>dioxolane

: 145439-99-2
(+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine

: 145439-98-1
(-)-(2R,4R)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-6-chloropurine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; Yield given. Yields of byproduct given; a) RT, 30 min, b) reflux, 14 h;
DOI:10.1021/jm00053a004