229635-18-1

Basic information

• Product Name: 1,3-Dioxolan-4-ol, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, acetate, (2R)-
• CAS NO: 229635-18-1
• Molecular Formula: C22H28O5Si
• Molecular Weight: 400.547
• Mol File: 229635-18-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolan-4-ol, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, acetate, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolan-4-ol, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, acetate, (2R)-(229635-18-1)
• EPA Substance Registry System: 1,3-Dioxolan-4-ol, 2-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, acetate, (2R)-(229635-18-1)

Safety Data

• Hazardous Substances Data: 229635-18-1(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 136884-14-5 (+)-(2R,4R)-2-<<(tert-butyldiphenylsilyl)oxy>methyl>dioxolane-4-carboxylic acid 
• 136884-13-4 (-)-(2R,4R,1'S)-2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(1,2-dihydroxyethyl)dioxolane 
• 546-67-8 lead(IV) tetraacetate 
• 141119-41-7 (+)-(2R,4R)-2-<<(tert-butyldiphenylsilyl)oxy>methyl>dioxolane-4-carboxylic acid methyl ester 

Downstream Products

• 141119-28-0 (+)-(2R,4S)-5-bromo-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>uracil 
• 141119-27-9 (+)-(2R,4R)-5-bromo-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>uracil 
• 145440-06-8 (-)-(2R,4R)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine 
• 145440-07-9 (+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>hypoxanthine 
• 145440-09-1 (-)-(2R,4R)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>adenine 
• 145440-10-4 (+)-(2R,4S)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>adenine 
• 145440-25-1 (-)-(2R,4R)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-2-chloro-N⁶-methyladenine 
• 136884-17-8 (+)-(2R,4S)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>thymine 
• 136884-16-7 (-)-(2R,4R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>thymine 
• 136982-90-6 (+)-(2R,4S)-1-<2-(hydroxymethyl)-1,3-dioxolan-4-yl>thymine 
• 136982-89-3 (-)-(2R,4R)-1-<2-(hydroxymethyl)-1,3-dioxolan-4-yl>thymine 
• 141119-24-6 (+)-(2R,4S)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-5-fluorouracil 
• 141119-23-5 (+)-(2R,4R)-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-5-fluorouracil 
• 145440-23-9 (-)-(2R,4R)-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-dioxolan-4-yl>-2,6-dichloropurine 

Relevant articles and documents

METHOD FOR THE PRODUCTION OF OH PROTECTED [4-(2.6-DIAMINO-9H-PURINE-9-YL)- 1.3-DIOXOLANE-2-YL]METHANOL DERIVATIVES

The invention relates to a method for the production of OH protected [4-(2,6-diamino-9H-purine-9-yl)-1,3-dioxolane-2- yl]methanol derivatives in a racemically or optically pure form by directly reacting 2.6-diaminopurine and/or a single or multiple silylated 2.6-diaminopurine with a sugar component. An auxiliary agent in the form of a 1.3- dicarbonyl compound or a silylated derivative of a 1.3 dicarbonyl compound is present during the reaction of the glycosylation, in addition to a Lewis acid.

Asymmetric synthesis of enantiomerically pure (-)-(1'R,4'R)-dioxolane-thymine and its anti-HIV activity

An asymmetric synthesis leading to the enantiomerically pure dioxolane-T has been achieved and its crystal structure has been determined and compared to the previously reported racemate. (-)-(1'R,4'R)-dioxolane-T was found to have potent and selective ant