cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene

Base Information

• Chemical Name: cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene
• CAS No.: 72474-41-0
• Molecular Formula: C₂₀H₁₆O
• Molecular Weight: 272.346
• Mol file: 72474-41-0.mol

Synonyms:cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene

Chemical Property of cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene

There total 9 articles about cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(Z)-4-(1-chloro-2-phenylvinyl)phenol + phenylmagnesium bromide (100-58-3) → cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene (72474-41-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; at 35 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201709070

Reference yield:

diphenyl acetylene (501-65-5) → cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene (72474-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) diisobutylaluminium hydride, 2.) tetrakis(triphenylphosphine) palladium / 1.) hexane, 55 deg C, 18 h, 2.) THF, reflux, 24 h

2: Ch₃CH₂SH, NaH / dimethylformamide / 10 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; diisobutylaluminium hydride; ethanethiol; In N,N-dimethyl-formamide;

Reference yield:

(E)-1-(4-methoxyphenyl)-1,2-diphenylethylene (1233-23-4,72474-39-6,72474-43-2) → cis-1,2-diphenyl-1-(p-hydroxyphenyl) ethylene (72474-41-0)

Guidance literature:

With sodium hydride; ethanethiol; In N,N-dimethyl-formamide; for 10h; Yield given; Heating;

upstream raw materials:

4-(1,2-diphenylvinyl)anisole

(E)-1-(4-methoxyphenyl)-1,2-diphenylethylene

1-bromo-4-methoxy-benzene

4-methoxyphenylzinc chloride

Downstream raw materials:

cis-1,2-diphenyl-1-<4-(2-diethylaminoethoxy)phenyl>ethylene