ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate

Base Information

Chemical Name:ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate
CAS No.:1219366-59-2
Molecular Formula:C₂₇H₃₆N₂O₄
Molecular Weight:452.594
Hs Code.:

Synonyms:ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate

Chemical Property:

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Technology Process of ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate

There total 2 articles about ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1219366-58-1
C₂HF₃O₂*C₂₂H₂₈N₂O₂

: 1219366-59-2
ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate

Guidance literature:: With sodium carbonate; In water; ethyl acetate; at 20 ℃; for 24h;

Reference yield:

: 1219366-56-9
C₂₉H₃₄N₂O₃S

: 1219366-59-2
ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2 h / 0 - 20 °C

2: sodium carbonate / water; ethyl acetate / 24 h / 20 °C

With sodium carbonate; In ethanol; water; ethyl acetate;
DOI:10.1021/acs.jmedchem.7b00377

Reference yield:

: 1219366-59-2
ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate

: 1219365-65-7
N-((1R,2S)-1-amino-1-cyclopropyl-3-(hydroxyamino)-3-oxopropan-2-yl)-4-(but-2-yn-1-yloxy)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium(II) hydroxide; hydrogen / ethanol / 12 h

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: hydroxylamine / water; methanol; acetonitrile / 20 °C

With hydrogen; hydroxylamine; palladium(II) hydroxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.jmedchem.7b00377