ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate

Base Information

Chemical Name:ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate
CAS No.:1219366-62-7
Molecular Formula:C₁₉H₂₄N₂O₄
Molecular Weight:344.411
Hs Code.:

Synonyms:ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate

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Chemical Property of ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate

Chemical Property:

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Technology Process of ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate

There total 7 articles about ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219366-61-6
ethyl (2S,3R)-2-(4-(but-2-yn-1-yloxy)benzamido)-3-((tert-butoxycarbonyl)amino)-3-cyclopropylpropanoate

: 1219366-62-7
ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1219366-59-2
ethyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-3-cyclopropyl-2-(dibenzylamino)propanoate

: 1219366-62-7
ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium(II) hydroxide; hydrogen / ethanol / 12 h

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With hydrogen; palladium(II) hydroxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; dichloromethane;
DOI:10.1021/acs.jmedchem.7b00377

Reference yield:

: 1219366-60-5
ethyl (2S,3R)-2-amino-3-((tert-butoxycarbonyl)amino)-3-cyclopropylpropanoate

: 1219366-62-7
ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-3-cyclopropylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;
DOI:10.1021/acs.jmedchem.7b00377