Methyl (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate

Base Information

Chemical Name:Methyl (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate
CAS No.:196394-49-7
Molecular Formula:C₁₂H₁₉NO₅
Molecular Weight:257.287
Hs Code.:
DSSTox Substance ID:DTXSID40448927
Wikidata:Q82268145
Mol file:196394-49-7.mol

Synonyms:196394-49-7;Methyl (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate;1-O-tert-butyl 2-O-methyl (2S,4R)-4-methyl-5-oxopyrrolidine-1,2-dicarboxylate;1-tert-Butyl 2-methyl (2S,4R)-4-methyl-5-oxopyrrolidine-1,2-dicarboxylate;SCHEMBL882834;DTXSID40448927;CS-0055516;P10798;Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate;1-tert-Butyl 2-methyl (2S,4R)-4-methyl-5-oxopyrrolidine-1, 2-dicarboxylate;(2S,4R)-4-Methyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Suppliers and Price of Methyl (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate
10mg
$ 120.00

TRC
Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate
100mg
$ 945.00

Medical Isotopes, Inc.
Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate
50 mg
$ 2000.00

Matrix Scientific
Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate 95+%
1g
$ 1782.00

Crysdot
Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate 95+%
1g
$ 1074.00

Chemenu
Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate 95%
1g
$ 1012.00

American Custom Chemicals Corporation
METHYL-(2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE 95.00%
5MG
$ 496.60

American Custom Chemicals Corporation
METHYL-(2S,4R)-1-(TERT-BUTOXYCARBONYL)-4-METHYLPYROGLUTAMATE 95.00%
1G
$ 1725.15

AK Scientific
Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate
1g
$ 1369.00

Total 6 raw suppliers

Chemical Property of Methyl (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate

Chemical Property:

Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:257.12632271
Heavy Atom Count:18
Complexity:371

Purity/Quality:

97% ^*data from raw suppliers

Methyl(2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(N(C1=O)C(=O)OC(C)(C)C)C(=O)OC
Isomeric SMILES:C[C@@H]1C[C@H](N(C1=O)C(=O)OC(C)(C)C)C(=O)OC
Uses Methyl (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate (cas# 196394-49-7) is a compound useful in organic synthesis.

Technology Process of Methyl (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate

There total 7 articles about Methyl (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 74-88-4
methyl iodide

: 158392-74-6
O₁-tert-butyl O₂-methyl (2S)-4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate

: 196394-49-7
(2S,4R)-1-(tert-butyl) 2-methyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate

: 196394-48-6
(2S,4S)-1-tert-butyl 2-methyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

methyl iodide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(03)00429-5

Reference yield:

: 219844-08-3
methyl (S)-1-tert-butoxycarbonyl-3-[(E)-(dimethylamino)methylidene]-2-pyrrolidinone-5-carboxylate

: 196394-49-7
(2S,4R)-1-(tert-butyl) 2-methyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate

: 196394-48-6
(2S,4S)-1-tert-butyl 2-methyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In isopropyl alcohol; at 45 ℃; for 18h; under 2327.23 Torr;

Reference yield:

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 74-88-4
methyl iodide

: 196394-49-7
(2S,4R)-1-(tert-butyl) 2-methyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate

: 196394-48-6
(2S,4S)-1-tert-butyl 2-methyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: (S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; for 5h;