4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 153473-24-6
• Molecular Formula: C₁₄H₂₀N₄O₄
• Molecular Weight: 308.337
• Hs Code.: 29335990
• Mol file: 153473-24-6.mol

Synonyms:4-(3-Nitropyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester;

Chemical Property of 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 3.26E-08mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 447.8 °C at 760 mmHg
• PKA: 4.38±0.29(Predicted)
• Flash Point: 224.6 °C
• PSA: 91.49000
• Density: 1.258 g/cm³
• LogP: 2.57300
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-(3-Nitropyridin-2-yl)piperazine ^*data from reagent suppliers

Safty Information:

• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 4 articles about 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-tert-butoxycarbonyl-4-(3-nitro-2-pyridyl)piperazine (153473-24-6)

Guidance literature:

With potassium carbonate; In water; acetonitrile; at 0 - 20 ℃; for 6.33h;

Reference yield: 81.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-(3-nitro-2-pyridinyl)piperazine (87394-48-7) → 1-tert-butoxycarbonyl-4-(3-nitro-2-pyridyl)piperazine (153473-24-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 1-tert-butoxycarbonyl-4-(3-nitro-2-pyridyl)piperazine (153473-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70.9 percent / diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

2: Et₃N / CH₂Cl₂

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1248/cpb.49.1406

upstream raw materials:

di-tert-butyl dicarbonate

1-(3-nitro-2-pyridinyl)piperazine

2-fluoro-3-nitropyridine

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

1-[1,1-Dimethylethoxycarbonyl]-4-[3-(propylamino)-2-pyridinyl]piperazine

1-[1,1-dimethylethoxycarbonyl]-4-[3-amino-2-pyridinyl]piperazine

4-(3-phenylsulfanyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-piperazine-1-carboxylic acid tert-butyl ester

4-(3-benzenesulfonyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-piperazine-1-carboxylic acid tert-butyl ester