87394-48-7

Basic information

• Product Name: 1-(3-Nitorpyridin-2-yl)piperazine
• Synonyms: 1-(3-Nitorpyridin-2-yl)piperazine2-yl)piperazine;1-(3-Nitorpyridin-2-yl)piperazine;1-(3-Nitropyridin-2-yl)piperazine ,97%;1-(3-nitropyridin-2-yl)piperazine dihydrochloride;piperazine, 1-(3-nitro-2-pyridinyl)-;1-(3-Nitro-2-pyridyl)piperazine, 97%
• CAS NO: 87394-48-7
• Molecular Formula: C₉H₁₂N₄O₂
• Molecular Weight: 208.22
• EINECS: 201-215-5
• Product Categories: pharmacetical;Pyridines
• Mol File: 87394-48-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 84-86
• Boiling Point: 387.8 °C at 760 mmHg
• Flash Point: 188.4 °C
• Appearance: /
• Density: 1.278 g/cm³
• Vapor Pressure: 3.2E-06mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: 2-8°C
• PKA: 8.25±0.10(Predicted)
• CAS DataBase Reference: 1-(3-Nitorpyridin-2-yl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Nitorpyridin-2-yl)piperazine(87394-48-7)
• EPA Substance Registry System: 1-(3-Nitorpyridin-2-yl)piperazine(87394-48-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 87394-48-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C9H12N4O2/c14-13(15)8-2-1-3-11-9(8)12-6-4-10-5-7-12/h1-3,10H,4-7H2

Upstream product

• 110-85-0 piperazine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 142-64-3 piperazine dihydrochloride 

Downstream Products

• 153473-24-6 1-tert-butoxycarbonyl-4-(3-nitro-2-pyridyl)piperazine 
• 1620488-60-9 1-(4-fluorophenyl)-2-imidazol-1-yl-ethyl 4-(3-nitro-2-pyridyl)piperazine-1-carboxylate 
• 111669-26-2 4-(3-ethylaminopyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 111669-24-0 4-[3-(Ethylamino)-2-pyridinyl]-piperazine 
• 403502-22-7 [2-chloro-5-(3-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-21-6 [2-chloro-5-(4-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-23-8 [2-chloro-5-(2-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-17-0 [4-[3-(isopropylamino)-2-pyridyl]piperazino]-[5-(4-nitrophenyl)-1H-2-pyrrolyl]methanone 
• 403502-19-2 [4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-[5-(3-nitro-phenyl)-1H-pyrrol-2-yl]-methanone 
• 403502-46-5 [5-(4-amino-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-41-0 [5-(2-amino-phenyl)-1H-pyrrol-2-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-20-5 [4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-[5-(2-nitro-phenyl)-1H-pyrrol-2-yl]-methanone 

Relevant articles and documents

PYRIMIDO[5,4-d]PYRIMIDINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS

The present invention relates to pyrimido[5,4-d]pyrimidine derivatives of formula (I), including pharmaceutically acceptable salts and solvates thereof. Compounds of the invention are inhibitors of ENT family transporter, especially of ENT1, and are useful as therapeutic compounds for the treatment of cancers. The invention also relates to the combined use of the pyrimido[5,4-d]pyrimidine derivatives with an adenosine receptor antagonist, for the treatment of cancers.

Strategy for 14C-labeling of a series of bis(heteroaryl) piperazines

Four bis(heteroaryl)piperazines labeled with carbon-14 in the 2-position of imidazole moiety were prepared as part of a 4-step (or 5-step) sequence from 5-hydroxymethyl-2-mercapto-1-benzylimida-zole-[2-14C] as a key synthetic intermediate which

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)

High-throughput screening of a small-molecule compound library resulted in the identification of a series of arylsulfonylpiperazines that are potent and selective inhibitors of human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). Optimization of the initial lead resulted in the discovery of compound (R)-45 (11β-HSD1 IC50 = 3 nM).