3-benzoylpropanal diethyl acetal

Base Information

• Chemical Name: 3-benzoylpropanal diethyl acetal
• CAS No.: 74327-27-8
• Molecular Formula: C₁₄H₂₀O₃
• Molecular Weight: 236.311
• Mol file: 74327-27-8.mol

Synonyms:3-benzoylpropanal diethyl acetal

Chemical Property of 3-benzoylpropanal diethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-benzoylpropanal diethyl acetal

There total 6 articles about 3-benzoylpropanal diethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethanol (64-17-5) + (E)-4-methoxy-1-phenylbut-2-en-1-one (131190-28-8) → 3-benzoylpropanal diethyl acetal (74327-27-8)

Guidance literature:

With water; RhCl(PPh₃)3; at 110 ℃; for 20h;

DOI:10.1016/S0040-4020(01)96010-7

Reference yield: 48.0%

2,2-diethoxy acetic acid (20461-86-3) + Phenyl vinyl ketone (768-03-6,26742-84-7) → 3-benzoylpropanal diethyl acetal (74327-27-8)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique; Irradiation;

DOI:10.1039/c7cc06252d

Reference yield:

Bromoacetaldehyde diethyl acetal (2032-35-1) → 3-benzoylpropanal diethyl acetal (74327-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / acetone / Heating

2: (i) LDA, THF, (ii) /BRN= 969256/, HMPT, (iii) tartaric acid, H₂O

With sodium iodide; In acetone;

DOI:10.1016/0040-4020(79)88003-5

upstream raw materials:

N-(1-phenylethylidene)cyclohexylamine

1,1-diethoxy-2-iodoethane

3-chloro-1,1-diethoxy-propane

N,N-diethylbenzamide

Downstream raw materials:

4-oxo-4-phenyl-butyraldehyde