1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Base Information

Chemical Name:1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)
CAS No.:167484-79-9
Molecular Formula:C₂₈H₃₆Cl₂N₂O₂S
Molecular Weight:535.578
Hs Code.:

Synonyms:1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

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Chemical Property of 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Chemical Property:

Purity/Quality:

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Technology Process of 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

There total 8 articles about 1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 164328-62-5
[(2S)-2-(3,4-dichloro-phenyl)-4-oxo-butyl]-methyl-carbamic acid tert-butyl ester

: spiro[2,3-dihydrobenzothiophene]-3,4'-piperidine hydrochloride

: 167484-79-9
1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Guidance literature:: With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1016/S0960-894X(00)00637-5

Reference yield:

: 3-(S)-(3,4-Dichlorophenyl)-4-(N-(t-butoxycarbonyl)methylamino)-butanal

: 167483-88-7
1'-(3-((S)-(3,4-dichlorophenyl))-4-(methylamino)butyl)-1-methanesulfonyl-spiro(indoline-3,4'-piperidine)

: 167484-79-9
1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Guidance literature:

Reference yield:

: 156300-02-6
(S)-2-(3,4-dichlorophenyl)pent-4-enoyl chloride

: 167484-79-9
1'-(3-((S)-(3,4-dichlorophenyl))-4-(N-(t-butoxycarbonyl)(methylamino))butyl)-spiro(2,3-dihydrobenzothiophene-3,4'-piperidine)

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 20 °C

2: LAH / tetrahydrofuran / 20 °C

3: DIPEA / CH₂Cl₂ / 20 °C

4: OsO₄; NMO / acetone; 2-methyl-propan-2-ol; H₂O / 20 °C

5: aq. NaIO₄ / tetrahydrofuran / 20 °C

6: NaBH(OAc)3; DIPEA / 1,2-dichloro-ethane / 20 °C

With sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; acetone; tert-butyl alcohol;
DOI:10.1016/S0960-894X(00)00637-5