156300-02-6

Basic information

• Product Name: (S)-2-(3,4-dichlorophenyl)pent-4-enoyl chloride
• Synonyms: (S)-2-(3,4-dichlorophenyl)pent-4-enoyl chloride
• CAS NO: 156300-02-6
• Molecular Weight: 263.551
• Mol File: 156300-02-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-2-(3,4-dichlorophenyl)pent-4-enoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(3,4-dichlorophenyl)pent-4-enoyl chloride(156300-02-6)
• EPA Substance Registry System: (S)-2-(3,4-dichlorophenyl)pent-4-enoyl chloride(156300-02-6)

Safety Data

• Hazardous Substances Data: 156300-02-6(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 147643-57-0 (2S)-2-(3,4-dichlorophenyl)pent-4-enoic acid 
• 6831-55-6 2-(3,4-dichlorophenyl)acetyl chloride 
• 250788-94-4 (S)-4-benzyl-3-(2-(3,4-dichlorophenyl)pent-4-enoyl)-2-oxazolidinone 
• 147643-58-1 (S)-4-benzyl-3-(3,4-dichlorophenyl)acetyl-2-oxazolidinone 
• 79333-48-5 2-(S)-(3,4-dichloro-phenyl)-4-pentenoic acid 
• 5807-30-7 3,4-dichlorophenyl acetic acid 

Downstream Products

• 173457-52-8 (2S)-2-(3,4-dichlorophenyl)pent-4-enal 
• 171595-58-7 (3R)-3-[(1S)-1-(3,4-dichlorophenyl)but-3-enyl]-2-ethyl-2,3-dihydroisoindol-1-one 
• 181765-84-4 [(S)-2-(3,4-Dichloro-phenyl)-pent-4-en-(E)-ylidene]-ethyl-amine 
• 209349-60-0 1'-(3-((S)-(3,4-Dichlorophenyl))-4-(N-(quinoline-8-sulfonyl) (methylamino))-butyl)-spiro(2.3-dihydrobenzothiophene-3,4'-piperidine) 

Relevant articles and documents

CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS

-

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 1: Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl) butanes

Screening of the Merck sample collection for compounds with CCR5 receptor binding afforded (2S)-2-(3,4-dichlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[spiro(2 ,3-dihydrobenzthiophene-3,4′-piperidin-1′-yl)]butane S-oxide (4) as a potent lead structure having an IC50 binding affinity of 35 nM. Herein, we describe the discovery of this lead structure and our initial structure-activity relationship studies directed toward the requirement for and optimization of the 1-amino fragment.

Addition of transiently-generated methyl o-lithiobenzoate to imines. An isoindolone annulation

Addition of phenyllithium to a mixture of an imine, methyl o-iodobenzoate, and BF3-etherate at -105°C gives good to excellent yields of isoindolones. The transient formation of methyl o-lithiobenzoate is proposed, which is formed by a rapid lithium/iodide exchange reaction of the phenyllithium with methyl o-iodobenzoate in the presence of the imine. The transiently generated anions can then be captured by the BF3-activated imines to form the isoindolones in good to high yield. The reactions conditions are sufficiently mild, and selective, to permit functional groups such carbmethoxy and aryl bromide, which could otherwise react with the added PhLi, to be tolerated.