trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-4-methylazetidin-2-one

Base Information

Chemical Name:trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-4-methylazetidin-2-one
CAS No.:745074-58-2
Molecular Formula:C₁₉H₂₀N₂O₃
Molecular Weight:324.379
Hs Code.:

Synonyms:trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-4-methylazetidin-2-one

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Chemical Property of trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-4-methylazetidin-2-one

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Technology Process of trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-4-methylazetidin-2-one

There total 2 articles about trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-4-methylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 745074-57-1
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one

: 745074-58-2
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-4-methylazetidin-2-one

Guidance literature:: With magnesium bis(monoperoxyphthalate)hexahydrate; In methanol; at 20 ℃; for 1h;
DOI:10.1021/ol0490328

Reference yield:

: 71922-59-3
N-benzyl-N-benzyloxycarbonyl-glycine

: 745074-58-2
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-4-methylazetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / i-Pr₂NEt; 2-chloro-N-methylpyridinium iodide / toluene / 6 h / 80 °C

2: 90 percent / magnesium monoperoxyphthalate*6H₂O / methanol / 1 h / 20 °C

With magnesium bis(monoperoxyphthalate)hexahydrate; 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In methanol; toluene;
DOI:10.1021/ol0490328