trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one

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Chemical Name:trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one
CAS No.:745074-57-1
Molecular Formula:C₂₅H₃₁N₃O₃
Molecular Weight:421.539
Hs Code.:

Synonyms:trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one

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Chemical Property of trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one

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Technology Process of trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one

There total 3 articles about trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 71922-59-3
N-benzyl-N-benzyloxycarbonyl-glycine

: 745074-56-0
(2R,5R)-1-(ethylideneamino)-2,5-dimethylpyrrolidine

: 745074-57-1
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In toluene; at 80 ℃; for 6h;
DOI:10.1021/ol0490328

Reference yield:

: 119008-52-5
(S,S)-2,5-bis(methylsulfonyloxy)hexane

: 745074-57-1
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine monohydrate / 20 °C

1.2: 300 mg / diethyl ether

2.1: 74 percent / i-Pr₂NEt; 2-chloro-N-methylpyridinium iodide / toluene / 6 h / 80 °C

With 2-chloro-1-methyl-pyridinium iodide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In toluene;
DOI:10.1021/ol0490328

Reference yield:

: 34338-96-0
(2S,5S)-2,5-hexanediol

: 745074-57-1
trans-(3R,4R)-3-[benzyl(benzyloxycarbonyl)amino]-1-[(2R,5R)-2,5-dimethylpyrrolidin-1-yl]-4-methylazetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂ / 3 h / 0 °C

2.1: hydrazine monohydrate / 20 °C

2.2: 300 mg / diethyl ether

3.1: 74 percent / i-Pr₂NEt; 2-chloro-N-methylpyridinium iodide / toluene / 6 h / 80 °C

With 2-chloro-1-methyl-pyridinium iodide; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/ol0490328