4-N-Boc-2-oxo-piperazine-1-acetic acid

Base Information

Chemical Name:4-N-Boc-2-oxo-piperazine-1-acetic acid
CAS No.:549506-47-0
Molecular Formula:C11H18N2O5
Molecular Weight:258.274
Hs Code.:29335990
European Community (EC) Number:675-923-0
DSSTox Substance ID:DTXSID10589235
Wikidata:Q72470209
Mol file:549506-47-0.mol

Synonyms:549506-47-0;4-N-Boc-2-oxo-piperazine-1-acetic acid;2-oxo-4-boc-1-piperazineacetic acid;2-(4-(tert-butoxycarbonyl)-2-oxopiperazin-1-yl)acetic acid;4-carboxymethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester;2-[4-[(2-methylpropan-2-yl)oxycarbonyl]-2-oxopiperazin-1-yl]acetic acid;4-boc-1-carboxymethylpiperazin-2-one;1-Piperazineaceticacid, 4-[(1,1-dimethylethoxy)carbonyl]-2-oxo-;MFCD04115297;2-Oxo-4-Boc-1-piperazineaceticacid;4-N-Boc-2-oxo-piperazine-1-aceticacid;SCHEMBL6873040;DTXSID10589235;QHPTYSXSHRLTHM-UHFFFAOYSA-N;2-{4-[(tert-butoxy)carbonyl]-2-oxopiperazin-1-yl}acetic acid;4-Boc-2-oxopiperazine-1-acetic Acid;AKOS015918885;4-boc-1-carboxymethyl-piperazin-2-one;AB19875;MCULE-7327857399;AS-36822;SY064298;AM20100355;CS-0035671;EN300-82963;A13649;J-510218;Z1238546570;[4-(TERT-BUTOXYCARBONYL)-2-OXOPIPERAZIN-1-YL]ACETIC ACID;2-[4-(TERT-BUTOXYCARBONYL)-2-OXO-1-PIPERAZINYL]ACETIC ACID

Suppliers and Price of 4-N-Boc-2-oxo-piperazine-1-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
4-Boc-1-carboxymethylpiperazin-2-one
250mg
$ 368.00

Matrix Scientific
2-[4-(tert-Butoxycarbonyl)-2-oxo-1-piperazinyl]acetic acid
10g
$ 2430.00

Matrix Scientific
2-[4-(tert-Butoxycarbonyl)-2-oxo-1-piperazinyl]acetic acid
5g
$ 1530.00

Matrix Scientific
2-[4-(tert-Butoxycarbonyl)-2-oxo-1-piperazinyl]acetic acid
1g
$ 720.00

J&W Pharmlab
4-Carboxymethyl-3-oxo-piperazine-1-carboxylicacidtert-butylester 96%
5g
$ 498.00

ChemScene
2-(4-(tert-Butoxycarbonyl)-2-oxopiperazin-1-yl)aceticacid
5g
$ 675.00

ChemScene
2-(4-(tert-Butoxycarbonyl)-2-oxopiperazin-1-yl)aceticacid
1g
$ 150.00

Chem-Impex
4-Boc-1-carboxymethylpiperazin-2-one,≥99%(HPLC) ≥99%(HPLC)
10G
$ 1089.09

Chem-Impex
4-Boc-1-carboxymethylpiperazin-2-one,≥99%(HPLC) ≥99%(HPLC)
1G
$ 174.72

Chem-Impex
4-Boc-1-carboxymethylpiperazin-2-one,≥99%(HPLC) ≥99%(HPLC)
5G
$ 559.10

Total 30 raw suppliers

Chemical Property of 4-N-Boc-2-oxo-piperazine-1-acetic acid

Chemical Property:

Vapor Pressure:1.37E-09mmHg at 25°C
Refractive Index:1.512
Boiling Point:456.2 °C at 760 mmHg
PKA:3.66±0.10(Predicted)
Flash Point:229.7 °C
PSA：87.15000
Density:1.263 g/cm³
LogP:0.02610
Storage Temp.:Store at 0-5°C
XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:258.12157168
Heavy Atom Count:18
Complexity:361

Purity/Quality:

97% ^*data from raw suppliers

4-Boc-1-carboxymethylpiperazin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(C(=O)C1)CC(=O)O

Technology Process of 4-N-Boc-2-oxo-piperazine-1-acetic acid

There total 1 articles about 4-N-Boc-2-oxo-piperazine-1-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76003-29-7
4-(t-butyloxycarbonyl)piperazin-2-one

: 549506-47-0
2-(4-(tert-butoxycarbonyl)-2-oxopiperazin-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 - 65 °C / Inert atmosphere

1.2: 2.5 h / 20 - 65 °C

2.1: sodium hydroxide; water / methanol / 2.5 h

2.2: pH 2 / Acidic conditions

With water; sodium hydride; sodium hydroxide; In methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield: 93.0%

: 367-65-7
3,5-bis(trifluoromethyl)-1,2-benzenediamine

: 549506-47-0
2-(4-(tert-butoxycarbonyl)-2-oxopiperazin-1-yl)acetic acid

: 1396396-64-7
tert-butyl 4-(2-((2-amino-3,5-bis(trifluoromethyl)phenyl)amino)-2-oxoethyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield: 85.0%

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 549506-47-0
2-(4-(tert-butoxycarbonyl)-2-oxopiperazin-1-yl)acetic acid

: C₁₉H₂₁F₆N₃O₄

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;