76003-29-7

Basic information

• Product Name: 1-Boc-3-oxopiperazine
• Synonyms: tert-Butyl 3-oxopiperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-oxopiperazine;1-Boc-oxopiperzine;1-Boc-3-oxopiperazine 3-Oxopiperazine-1-carboxylic Acid tert-Butyl Ester;1-(tert-Butoxycarbonyl)piperazin-3-one;1-Boc-3-oxopiperazine 98%;1-Boc-3-oxopiperazine SynonyMs 4-N-Boc-2-oxo-piperazine;1-Boc-3-oxopiperazine,98%;1-Piperazinecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester
• CAS NO: 76003-29-7
• Molecular Formula: C₉H₁₆N₂O₃
• Molecular Weight: 200.23
• Product Categories: Building Blocks;C9;Chemical Synthesis;Heterocyclic Building Blocks;pharmacetical;Building Blocks;Heterocyclic Building Blocks;Piperazines
• Mol File: 76003-29-7.mol
• Article Data: 51

Chemical Properties

• Melting Point: 156-160 °C(lit.)
• Boiling Point: 359.1 °C at 760 mmHg
• Flash Point: 171 °C
• Appearance: White to off-white/Crystalline Powder
• Density: 1.129 g/cm³
• Vapor Pressure: 2.44E-05mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 15.01±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-3-oxopiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-oxopiperazine(76003-29-7)
• EPA Substance Registry System: 1-Boc-3-oxopiperazine(76003-29-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 76003-29-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

Uses

4-Boc-2-oxopiperazine is used in the synthesis of renin inhibitors. Also used in the synthesis of isoindoline inhibitors of dipeptidyl peptidases.

InChI:InChI=1/C9H16N2O3/c1-9(2,3)14-8(13)11-5-4-10-7(12)6-11/h4-6H2,1-3H3,(H,10,12)

Upstream product

• 5625-67-2 2-Ketopiperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 107-06-2 1,2-dichloro-ethane 
• 105-39-5 chloroacetic acid ethyl ester 
• 75-65-0 tert-butyl alcohol 
• 179051-25-3 1-(2-naphthylmethyl)-2-oxopiperazine trifluoroacetate salt 

Downstream Products

• 914104-09-9 tert-butyl 4-[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)benzyl]-3-oxopiperazine-1-carboxylate 
• 786683-69-0 tert-butyl 4-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-3-oxo-piperazine-1-carboxylate 
• 866335-41-3 tert-butyl 4-propenyl-3-oxopiperazine-1-carboxylate 
• 78551-60-7 1-benzyl-4-(tert-butyloxycarbonyl)piperazin-2-one 
• 194351-12-7 1-tert-butoxycarbonyl-4-(2-fluoroethyl)-3-oxopiperazine 
• 239073-38-2 4-(tert-butoxycarbonyl)-1-(4-nitrobenzyl)-2-piperazinone 
• 367268-98-2 4-[2-fluoro-5-(methanesulfonyloxy)-benzyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester 
• 239073-60-0 methyl 3-(1-benzyloxycarbonylpiperidin-4-yl)-3-[4-(tert-butoxycarbonyl)-2-oxopiperazine-1-yl]propionate 
• 194350-95-3 tert-butyl 4-ethyl-3-oxopiperazine-1-carboxylate 
• 5625-67-2 2-Ketopiperazine 
• 198896-20-7 tert-butyl 4-(3-(1,3-dioxoisoindolin-2-yl)propyl)-3-oxopiperazine-1-carboxylate 

Relevant articles and documents

Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation

Alzheime?s disease (AD) is the most prominent neurodegenerative disorder with high medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where β-amyloid structures (Aβ) build toxic oligomers. Design of disease modifying multi target directed ligand (MTDL) has been performed, which disable PPI on the one hand and on the other hand, act as procognitive antagonists at the histamine H3 receptor (H3R). The synthetized compounds are structurally based on peptidomimetic amino acid-like structures mainly as keto, diketo-, or acyl variations of a piperazine moiety connected to an H3R pharmacophore. Most of them showed low nanomolar affinities at H3R and some with promising affinity to Aβ-monomers. The structure–activity relationships (SAR) described offer new possibilities for MTDL with an optimized profile combining symptomatic and potential causal therapeutic approaches in AD.

The hydrophobically-tagged MDM2-p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a

We present the first application of hydrophobic tagging to a non-covalent inhibitor of protein-protein interactions. Nutlin-3a-HT, created by fusing the hydrophobic tag HyT13 to the MDM2-p53 interaction inhibitor Nutlin-3a, prevented cellular accumulation of MDM2 upon p53 reactivation, and had a stronger effect on cell viability and the induction of apoptosis than Nutlin-3a.

PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.