diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate

Base Information

Chemical Name:diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate
CAS No.:1533457-22-5
Molecular Formula:C₂₅H₃₀NO₈P
Molecular Weight:503.489
Hs Code.:

Synonyms:diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate

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Chemical Property of diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate

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Technology Process of diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate

There total 4 articles about diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 885126-83-0
(S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanoic acid

: 1112455-41-0
α-O,O'-diethyl amino(3-methoxyphenyl)methylphosphonate

: 1533457-22-5
diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 20 ℃; Cooling with ice;
DOI:10.1007/s00044-013-0899-3

Reference yield:

: 90-33-5,79566-13-5
7-hydroxy-4-methyl-chromen-2-one

: 1533457-22-5
diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 13 h / 56 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 20 °C / Cooling with ice

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; acetone;
DOI:10.1007/s00044-013-0899-3

Reference yield:

: 108-46-3
recorcinol

: 1533457-22-5
diethyl ((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)(3-methoxyphenyl)methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogen sulfate / 20 °C

2: potassium carbonate / acetone / 13 h / 56 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 20 °C / Cooling with ice

With sodium hydrogen sulfate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; acetone; 1: |Pechmann Condensation;
DOI:10.1007/s00044-013-0899-3