(S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

Base Information

Chemical Name:(S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate
CAS No.:1391932-27-6
Molecular Formula:C₂₀H₂₁N₃O₃
Molecular Weight:351.405
Hs Code.:

Synonyms:(S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

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Chemical Property of (S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

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Technology Process of (S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

There total 1 articles about (S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1354894-23-7
(S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoic acid

: 302-15-8
methylhydrazine sulfuric acid

: 1391932-27-6
(S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: (S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -25 ℃; for 1h; Inert atmosphere;

methylhydrazine sulfuric acid; With sodium hydroxide; In tetrahydrofuran; water; at -25 - 25 ℃; for 24h;
DOI:10.1002/chem.201103322

Reference yield: 87.0%

: 1391932-27-6
(S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

: 100-52-7
benzaldehyde

: 1391932-28-7
(S,E)-4-ethynylbenzyl 1-(2-benzylidene-1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: With magnesium sulfate; In tetrahydrofuran; at 25 ℃; for 16h; Inert atmosphere;
DOI:10.1002/chem.201103322

Reference yield:

: 1391932-27-6
(S)-4-ethynylbenzyl 1-(1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

: 1391932-29-8
(S)-4-ethynylbenzyl 1-(2-benzyl-1-methylhydrazinyl)-1-oxo-3-phenylpropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / tetrahydrofuran / 16 h / 25 °C / Inert atmosphere

2.1: dimethylamine borane; toluene-4-sulfonic acid / methanol; dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

2.2: 0.5 h

With dimethylamine borane; magnesium sulfate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/chem.201103322