tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate

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Chemical Name:tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate
CAS No.:196696-26-1
Molecular Formula:C₃₅H₃₅ClN₂O₉S
Molecular Weight:695.19
Hs Code.:

Synonyms:tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate

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Chemical Property of tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate

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Technology Process of tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate

There total 4 articles about tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16357-59-8
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

: 196696-08-9
2-(3-Carboxy-2-hydroxybenzyl)-6-(2-hydroxybenzyl)-4-chlorophenol

: 196696-26-1
tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate

Guidance literature:: With ammonium sulfate; In tetrahydrofuran; 1,1,1,3,3,3-hexamethyl-disilazane;

Reference yield:

: 196696-22-7
2-(3-acetyl-5-bromo-2-hydroxybenzyl)-6-(5-bromo-2-hydroxybenzyl)-4-chlorophenol

: 196696-26-1
tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / aq. NaOH, I₂, KI / 0.5 h / Heating

2: 87 percent / 40percent aq. KOH, Zn / 5 h / Heating

3: 1.) 1,1,1,3,3,3-hexamethyldisilazane, ammonium sulfate, 2.) 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / 1.) reflux, 5 h, 2.) THF, RT, 24 h

With potassium hydroxide; sodium hydroxide; ammonium sulfate; iodine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1,1,1,3,3,3-hexamethyl-disilazane; potassium iodide; zinc;

Reference yield:

: 196696-23-8
2-(5-bromo-3-carboxy-2-hydroxybenzyl)-6-(5-bromo-2-hydroxybenzyl)-4-chlorophenol

: 196696-26-1
tert-Butyl 7-{3-[5-Chloro-2-hydroxy-3-(2-hydroxybenzyl)benzyl]-2-hydroxybenzamido}cephalosporanate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 40percent aq. KOH, Zn / 5 h / Heating

2: 1.) 1,1,1,3,3,3-hexamethyldisilazane, ammonium sulfate, 2.) 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline / 1.) reflux, 5 h, 2.) THF, RT, 24 h

With potassium hydroxide; ammonium sulfate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1,1,1,3,3,3-hexamethyl-disilazane; zinc;