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Product FOB Price Min.Order Supply Ability Supplier
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline TOP1 supplier
Cas No: 16357-59-8
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 2-Ethoxy-1-Ethoxycarbonyl-1,2-Dihydroquinoline supplier in China
Cas No: 16357-59-8
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
Cas No: 16357-59-8
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Ethyl 2-ethoxyquinoline-1(2H)-carboxylate
Cas No: 16357-59-8
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
1,2-Dihydro-2-ethoxy-1-quinolinecarboxylic acid ethyl ester
Cas No: 16357-59-8
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 16357-59-8
Cas No: 16357-59-8
No Data 1 Kilogram 10 Metric Ton/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier
Pharmaceutical Grade CAS 16357-59-8 with competitive price
Cas No: 16357-59-8
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline CAS 16357-59-8
Cas No: 16357-59-8
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
1(2H)-Quinolinecarboxylicacid, 2-ethoxy-, ethyl ester 16357-59-8
Cas No: 16357-59-8
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 99%
Cas No: 16357-59-8
USD $ 97.0-98.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Baoji Guokang Healthchem co.,ltd Contact Supplier

16357-59-8 Usage

Uses

Peptide condensing agent with little or no racemization. Amidation coupling reagent.

Uses

In the synthesis of peptides.

Purification Methods

Dissolve EEDQ ~180g in CHCl3, evaporate to dryness in a vacuum. Add dry Et2O (20mL) and a white solid separates on standing. Set aside for a few hours, collect the solid, wash it thoroughly with cold Et2O and dry it in a vacuum (~140g, m 63.5-65o). A further crop of solid (~25g) is obtained from the filtrate on standing overnight. [Fieser & Fieser Reagents for Organic Synthesis 2 191 1969, Belleau et al. J Am Chem Soc 90 823 1968 and 90 1651 1968, Beilstein 21/3 V 28.]

Chemical Properties

White to pale yellow solid
InChI:InChI=1/C14H17NO3/c1-3-17-13-10-9-11-7-5-6-8-12(11)15(13)14(16)18-4-2/h5-10,13H,3-4H2,1-2H3/t13-/m1/s1

16357-59-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (149837)  2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline  ≥99% 16357-59-8 149837-100G 2,254.59CNY Detail
Aldrich (149837)  2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline  ≥99% 16357-59-8 149837-25G 679.77CNY Detail
Aldrich (149837)  2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline  ≥99% 16357-59-8 149837-5G 182.52CNY Detail
Alfa Aesar (A13724)  2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%    16357-59-8 250g 4269.0CNY Detail
Alfa Aesar (A13724)  2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%    16357-59-8 50g 1214.0CNY Detail
Alfa Aesar (A13724)  2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline, 99%    16357-59-8 10g 323.0CNY Detail
TCI America (E0363)  1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline  >98.0%(HPLC)(T) 16357-59-8 25g 690.00CNY Detail

16357-59-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

1.2 Other means of identification

Product number -
Other names 1-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16357-59-8 SDS

16357-59-8Synthetic route

quinoline
91-22-5

quinoline

ethanol
64-17-5

ethanol

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 0℃; for 1.33333h;69%
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

acetone
67-64-1

acetone

ethyl 4-(2-hydroxypropan-2-yl)quinoline-1(4H)-carboxylate

ethyl 4-(2-hydroxypropan-2-yl)quinoline-1(4H)-carboxylate

Conditions
ConditionsYield
With diethylzinc; palladium diacetate; triphenylphosphine In toluene at 20℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; regioselective reaction;100%
propylamine
107-10-8

propylamine

indole-3-glycolic acid
3050-37-1

indole-3-glycolic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid ethyl ester (1H-indol-3-yl)-propylcarbamoyl-methyl ester

carbonic acid ethyl ester (1H-indol-3-yl)-propylcarbamoyl-methyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;99%
indole-3-glycolic acid
3050-37-1

indole-3-glycolic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

aniline
62-53-3

aniline

carbonic acid ethyl ester (1H-indol-3-yl)-phenylcarbamoyl-methyl ester

carbonic acid ethyl ester (1H-indol-3-yl)-phenylcarbamoyl-methyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;99%
indole-3-glycolic acid
3050-37-1

indole-3-glycolic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

ethoxycarbonyloxy-(1H-indol-3-yl)-acetic acid

ethoxycarbonyloxy-(1H-indol-3-yl)-acetic acid

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;99%
propylamine
107-10-8

propylamine

2-hydroxy-octanoic acid
617-73-2

2-hydroxy-octanoic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid ethyl ester 1-propylcarbamoyl-heptyl ester

carbonic acid ethyl ester 1-propylcarbamoyl-heptyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;99%
propylamine
107-10-8

propylamine

phenyllactic acid
828-01-3

phenyllactic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid ethyl ester 2-phenyl-1-propylcarbamoyl-ethyl ester

carbonic acid ethyl ester 2-phenyl-1-propylcarbamoyl-ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;99%
phenyllactic acid
828-01-3

phenyllactic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

2-ethoxycarbonyloxy-3-phenyl-propionic acid

2-ethoxycarbonyloxy-3-phenyl-propionic acid

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;99%
phenyllactic acid
828-01-3

phenyllactic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

benzylamine
100-46-9

benzylamine

carbonic acid 1-benzylcarbamoyl-2-phenyl-ethyl ester ethyl ester

carbonic acid 1-benzylcarbamoyl-2-phenyl-ethyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;99%
methyl 2-(bromomethyl)propenoate
4224-69-5

methyl 2-(bromomethyl)propenoate

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

2-(2-methoxycarbonyl-allyl)-2H-quinoline-1-carboxylic acid ethyl ester

2-(2-methoxycarbonyl-allyl)-2H-quinoline-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With indium; acetic acid In tetrahydrofuran for 0.5h;99%
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

3-methylthiophenylboronic acid
128312-11-8

3-methylthiophenylboronic acid

C19H19NO2S
1497411-35-4

C19H19NO2S

Conditions
ConditionsYield
With methallylnickel chloride dimer; sodium phenoxide; (1R,7R)-9,9-dimethyl-2,2,6,6-tetra(napht-2-yl)-4-phenyl-3,5,8,10-tetraoxa-4-phosphabicyclo<5.3.0>decane In 1,4-dioxane; tert-Amyl alcohol at 20℃; for 25h; Suzuki Coupling; Inert atmosphere; enantioselective reaction;99%
indole-3-glycolic acid
3050-37-1

indole-3-glycolic acid

di-n-propylamine
142-84-7

di-n-propylamine

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid dipropylcarbamoyl-(1H-indol-3-yl)-methyl ester ethyl ester

carbonic acid dipropylcarbamoyl-(1H-indol-3-yl)-methyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;98%
indole-3-glycolic acid
3050-37-1

indole-3-glycolic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

benzylamine
100-46-9

benzylamine

carbonic acid benzylcarbamoyl-(1H-indol-3-yl)-methyl ester ethyl ester

carbonic acid benzylcarbamoyl-(1H-indol-3-yl)-methyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;98%
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

benzylamine
100-46-9

benzylamine

ethoxycarbonyloxy-phenyl-acetic acid benzylamide
101730-29-4

ethoxycarbonyloxy-phenyl-acetic acid benzylamide

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;98%
2-hydroxy-octanoic acid
617-73-2

2-hydroxy-octanoic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

aniline
62-53-3

aniline

carbonic acid ethyl ester 1-phenylcarbamoyl-heptyl ester

carbonic acid ethyl ester 1-phenylcarbamoyl-heptyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;98%
di-n-propylamine
142-84-7

di-n-propylamine

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid dipropylcarbamoyl-phenyl-methyl ester ethyl ester

carbonic acid dipropylcarbamoyl-phenyl-methyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;97%
propylamine
107-10-8

propylamine

LACTIC ACID
849585-22-4

LACTIC ACID

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid ethyl ester 1-propylcarbamoyl-ethyl ester

carbonic acid ethyl ester 1-propylcarbamoyl-ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;97%
phenyllactic acid
828-01-3

phenyllactic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

aniline
62-53-3

aniline

carbonic acid ethyl ester 2-phenyl-1-phenylcarbamoyl-ethyl ester

carbonic acid ethyl ester 2-phenyl-1-phenylcarbamoyl-ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;97%
bis(1,5-cyclooctadiene)nickel (0)
1295-35-8

bis(1,5-cyclooctadiene)nickel (0)

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

bis[2-(diphenylphosphino)phenyl] ether
166330-10-5

bis[2-(diphenylphosphino)phenyl] ether

C50H43NNiO4P2

C50H43NNiO4P2

Conditions
ConditionsYield
Stage #1: bis(1,5-cyclooctadiene)nickel (0); bis[2-(diphenylphosphino)phenyl] ether In toluene at 23℃; for 0.333333h; Inert atmosphere;
Stage #2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In toluene for 1h; Inert atmosphere;
97%
fur-2-ylboronic acid
13331-23-2

fur-2-ylboronic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

2-furan-2-yl-2H-quinoline-1-carboxylic acid ethyl ester

2-furan-2-yl-2H-quinoline-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1h;96.4%
phenyllactic acid
828-01-3

phenyllactic acid

di-n-propylamine
142-84-7

di-n-propylamine

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid 1-dipropylcarbamoyl-2-phenyl-ethyl ester ethyl ester

carbonic acid 1-dipropylcarbamoyl-2-phenyl-ethyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;96%
t-Boc-L-valine
13734-41-3

t-Boc-L-valine

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

Boc-Val-O-COOEt
98807-40-0

Boc-Val-O-COOEt

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one In dichloromethane at 23℃; for 2h;95%
2-hydroxy-4-methylpentanoic acid
10303-64-7

2-hydroxy-4-methylpentanoic acid

di-n-propylamine
142-84-7

di-n-propylamine

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid 1-dipropylcarbamoyl-3-methyl-butyl ester ethyl ester

carbonic acid 1-dipropylcarbamoyl-3-methyl-butyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;95%
2-hydroxy-octanoic acid
617-73-2

2-hydroxy-octanoic acid

di-n-propylamine
142-84-7

di-n-propylamine

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid 1-dipropylcarbamoyl-heptyl ester ethyl ester

carbonic acid 1-dipropylcarbamoyl-heptyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;95%
propylamine
107-10-8

propylamine

2-hydroxy-4-methylpentanoic acid
10303-64-7

2-hydroxy-4-methylpentanoic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid ethyl ester 3-methyl-1-propylcarbamoyl-butyl ester

carbonic acid ethyl ester 3-methyl-1-propylcarbamoyl-butyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;95%
2-hydroxy-4-methylpentanoic acid
10303-64-7

2-hydroxy-4-methylpentanoic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

benzylamine
100-46-9

benzylamine

carbonic acid 1-benzylcarbamoyl-3-methyl-butyl ester ethyl ester

carbonic acid 1-benzylcarbamoyl-3-methyl-butyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;95%
2-hydroxy-octanoic acid
617-73-2

2-hydroxy-octanoic acid

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

benzylamine
100-46-9

benzylamine

carbonic acid 1-benzylcarbamoyl-heptyl ester ethyl ester

carbonic acid 1-benzylcarbamoyl-heptyl ester ethyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;95%
N-tert.-butoxycarbonyl-(3-benzothienyl)glycine

N-tert.-butoxycarbonyl-(3-benzothienyl)glycine

p-nitrobenzyl 7-amino-3-methyl-3-cephem-4-carboxylate

p-nitrobenzyl 7-amino-3-methyl-3-cephem-4-carboxylate

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

p-nitrobenzyl D,L-7-[N-tert.-butoxycarbonyl-(3-benzothienyl)glycylamido]-3-methyl-3-cephem-4-carboxylate

p-nitrobenzyl D,L-7-[N-tert.-butoxycarbonyl-(3-benzothienyl)glycylamido]-3-methyl-3-cephem-4-carboxylate

Conditions
ConditionsYield
With hydrogenchloride; sodium hydrogencarbonate In tetrahydrofuran; water; ethyl acetate; acetonitrile95%
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

ethyl-3-azido-4-chloro-2-ethoxy-3,4-dihydroquinoline-1(2H)-carboxylate

ethyl-3-azido-4-chloro-2-ethoxy-3,4-dihydroquinoline-1(2H)-carboxylate

Conditions
ConditionsYield
With chlorine azide In water; toluene at 20℃; for 0.0188889h; Flow reactor;95%
propylamine
107-10-8

propylamine

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

carbonic acid ethyl ester phenyl-propylcarbamoyl-methyl ester

carbonic acid ethyl ester phenyl-propylcarbamoyl-methyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;94%
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
16357-59-8

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

aniline
62-53-3

aniline

carbonic acid ethyl ester phenyl-phenylcarbamoyl-methyl ester

carbonic acid ethyl ester phenyl-phenylcarbamoyl-methyl ester

Conditions
ConditionsYield
In dichloromethane for 5h; Ambient temperature;94%

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