(2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal

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Chemical Name:(2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal
CAS No.:223565-02-4
Molecular Formula:C₃₈H₅₄O₅Si
Molecular Weight:618.929
Hs Code.:

(2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal

Synonyms:(2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal

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Chemical Property of (2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal

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Technology Process of (2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal

There total 11 articles about (2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 223564-99-6
(2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanol

: 223565-02-4
(2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1039/b008159k

Reference yield: 80.0%

: {(2R,4R,5S,7R,9R,10R,12S)-9-[(S)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxa-dispiro[4.1.5.3]pentadec-13-en-2-yl}-methanol

: 223565-02-4
(2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal

Guidance literature:: With N-methyl-2-indolinone; tetrapropylammonium perruthennate; In dichloromethane;
DOI:10.1055/s-1999-2607

Reference yield:

: 130514-54-4
(1'S,3R,5S,6S)-(+)-6-<1'-(t-butyldiphenylsilyloxymethyl)propyl>-3,5-dimethyltetrahydropyran-2-one

: 223565-02-4
(2'R,4'R,5'R,7'S,9'S,10'S,12'R,1''S)-{9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-2-yl}methanal

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C

2.1: Amberlite resin IR 118

3.1: 90 mg / Et₃N; 4-DMAP / CH₂Cl₂ / 1 h / 20 °C

4.1: H₂; K₂CO₃ / Lindlar catalyst / pentane; ethyl acetate / 1 h / 20 °C

5.1: 40 mg / pyridinium toluene-p-sulfonate / CH₂Cl₂ / 0.5 h / 20 °C

6.1: 36 percent / PhI(OAc)2; I₂ / cyclohexane / 7 h / 20 °C / Irradiation

7.1: 53 percent / K₂CO₃ / methanol / 1.5 h / 20 °C

8.1: 80 percent / N-methylmorpholine N-oxide; tetra-n-propylammonium perruthenate; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 20 °C

With dmap; n-butyllithium; tetrapropylammonium perruthennate; [bis(acetoxy)iodo]benzene; 4 A molecular sieve; Amberlite resin IR 118; hydrogen; iodine; pyridinium p-toluenesulfonate; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; Lindlar's catalyst; In tetrahydrofuran; methanol; hexane; dichloromethane; cyclohexane; ethyl acetate; pentane;
DOI:10.1039/b008159k