(2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

Base Information

Chemical Name:(2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene
CAS No.:337533-69-4
Molecular Formula:C₄₄H₆₆O₆Si
Molecular Weight:719.09
Hs Code.:

(2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

Synonyms:

Suppliers and Price of (2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

There total 12 articles about (2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223565-08-0
(E)-(2R,4R,5R,7S,9S,10S,12R,1'S,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-ethyl-2-(1-hydroxy-4-methylhex-4-en-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

: 337533-69-4
(2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

Guidance literature:: With 3,3-dimethyldioxirane; potassium carbonate; In acetone; at 0 ℃; for 1h;
DOI:10.1039/b008159k

Reference yield:

: 130514-54-4
(1'S,3R,5S,6S)-(+)-6-<1'-(t-butyldiphenylsilyloxymethyl)propyl>-3,5-dimethyltetrahydropyran-2-one

: 337533-69-4
(2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C

2.1: Amberlite resin IR 118

3.1: 90 mg / Et₃N; 4-DMAP / CH₂Cl₂ / 1 h / 20 °C

4.1: H₂; K₂CO₃ / Lindlar catalyst / pentane; ethyl acetate / 1 h / 20 °C

5.1: 40 mg / pyridinium toluene-p-sulfonate / CH₂Cl₂ / 0.5 h / 20 °C

6.1: 36 percent / PhI(OAc)2; I₂ / cyclohexane / 7 h / 20 °C / Irradiation

7.1: 53 percent / K₂CO₃ / methanol / 1.5 h / 20 °C

8.1: 80 percent / N-methylmorpholine N-oxide; tetra-n-propylammonium perruthenate; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 20 °C

9.1: Mg / diethyl ether

9.2: 70 percent / diethyl ether / 2 h / Heating

10.1: dimethyldioxirane; K₂CO₃ / acetone / 1 h / 0 °C

With dmap; n-butyllithium; tetrapropylammonium perruthennate; [bis(acetoxy)iodo]benzene; 4 A molecular sieve; Amberlite resin IR 118; hydrogen; iodine; 3,3-dimethyldioxirane; pyridinium p-toluenesulfonate; potassium carbonate; magnesium; 4-methylmorpholine N-oxide; triethylamine; Lindlar's catalyst; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; ethyl acetate; acetone; pentane; 9.2: Barbier reaction;
DOI:10.1039/b008159k

Reference yield:

: 223564-89-4
(2R,4R,5S/R,2'S/R,3'R,5'S,6'S,1''S)-8-{6-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-methoxy-3,5-dimethyltetrahydro-2H-pyran-2-yl}-2-ethyl-2,5-dihydroxy-4-methyloct-7-yn-1-yl acetate

: 337533-69-4
(2R,4R,5R,7S,9S,10S,12R,1'R/S,4'S/R,5'S/R,1''S)-9-[1-(tert-Butyldiphenylsilyloxymethyl)propyl]-2-(4,5-epoxy-1-hydroxy-4-methylhexan-1-yl)-4,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-ene

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂; K₂CO₃ / Lindlar catalyst / pentane; ethyl acetate / 1 h / 20 °C

2.1: 40 mg / pyridinium toluene-p-sulfonate / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 36 percent / PhI(OAc)2; I₂ / cyclohexane / 7 h / 20 °C / Irradiation

4.1: 53 percent / K₂CO₃ / methanol / 1.5 h / 20 °C

5.1: 80 percent / N-methylmorpholine N-oxide; tetra-n-propylammonium perruthenate; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 20 °C

6.1: Mg / diethyl ether

6.2: 70 percent / diethyl ether / 2 h / Heating

7.1: dimethyldioxirane; K₂CO₃ / acetone / 1 h / 0 °C

With tetrapropylammonium perruthennate; [bis(acetoxy)iodo]benzene; 4 A molecular sieve; hydrogen; iodine; 3,3-dimethyldioxirane; pyridinium p-toluenesulfonate; potassium carbonate; magnesium; 4-methylmorpholine N-oxide; Lindlar's catalyst; In methanol; diethyl ether; dichloromethane; cyclohexane; ethyl acetate; acetone; pentane; 6.2: Barbier reaction;
DOI:10.1039/b008159k