2,5-Difluoro-D-phenylalanine

Base Information

Chemical Name:2,5-Difluoro-D-phenylalanine
CAS No.:266360-61-6
Molecular Formula:C₉H₉F₂NO₂
Molecular Weight:201.173
Hs Code.:2922499990
European Community (EC) Number:674-659-3
DSSTox Substance ID:DTXSID90351992
Mol file:266360-61-6.mol

Synonyms:2,5-Difluoro-D-phenylalanine;266360-61-6;(r)-2-amino-3-(2,5-difluorophenyl)propanoic acid;(2R)-2-amino-3-(2,5-difluorophenyl)propanoic acid;d-2,5-difluorophenylalanine;(R)-2-Amino-3-(2,5-difluorophenyl)propanoicacid;(r)-2-amino-3-(2,5-difluoro-phenyl)-propionic acid;D-Phenylalanine,2,5-difluoro-;DTXSID90351992;MFCD07371999;AKOS012010226;AS-37653;CS-0170902;A818535;(r)-2-amino-3-(2,5-difluorophenyl)propionic acid

Suppliers and Price of 2,5-Difluoro-D-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,5-Difluoro-D-phenylalanine
100mg
$ 65.00

Crysdot
(R)-2-Amino-3-(2,5-difluorophenyl)propanoicacid 97%
5g
$ 611.00

Chemenu
2,5-Difluoro-D-Phenylalanine 97%
5g
$ 571.00

Apolloscientific
2,5-Difluoro-D-phenylalanine 97%
1g
$ 512.00

Apolloscientific
2,5-Difluoro-D-phenylalanine 97%
500mg
$ 321.00

Apolloscientific
2,5-Difluoro-D-phenylalanine 97%
250mg
$ 201.00

American Custom Chemicals Corporation
2,5-DIFLUORO-D-PHENYLALANINE 95.00%
1G
$ 825.89

Alichem
(R)-2-Amino-3-(2,5-difluorophenyl)propanoicacid
1g
$ 277.34

Alichem
(R)-2-Amino-3-(2,5-difluorophenyl)propanoicacid
5g
$ 849.00

AK Scientific
(R)-2-Amino-3-(2,5-difluorophenyl)propanoicacid
5g
$ 1221.00

Total 25 raw suppliers

Chemical Property of 2,5-Difluoro-D-phenylalanine

Chemical Property:

Vapor Pressure:0.00039mmHg at 25°C
Refractive Index:1.536
Boiling Point:304.2 °C at 760 mmHg
PKA:2.17±0.15(Predicted)
Flash Point:137.8 °C
PSA：63.32000
Density:1.379 g/cm³
LogP:1.61950
Storage Temp.:2-8°C
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:201.06013485
Heavy Atom Count:14
Complexity:213

Purity/Quality:

97% ^*data from raw suppliers

2,5-Difluoro-D-phenylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)CC(C(=O)O)N)F
Isomeric SMILES:C1=CC(=C(C=C1F)C[C@H](C(=O)O)N)F

Technology Process of 2,5-Difluoro-D-phenylalanine

There total 10 articles about 2,5-Difluoro-D-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 266360-55-8
(R)-2-Acetylamino-3-(2,5-difluoro-phenyl)-propionic acid

: 266360-61-6
(R)-2-Amino-3-(2,5-difluoro-phenyl)-propionic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; for 5h; Heating;
DOI:10.1016/S0040-4039(99)02191-7

Reference yield:

: 266360-49-0
2-acetylamino-3-(2,5-difluoro-phenyl)-propionic acid

: 31105-92-7,266360-61-6
(S)-2-Amino-3-(2,5-difluoro-phenyl)-propionic acid

: 266360-55-8
(R)-2-Acetylamino-3-(2,5-difluoro-phenyl)-propionic acid

Guidance literature:: With sodium hydroxide; Aspergillus genus acylase; sodium acetate; In water; at 38 ℃; for 48h; pH=8.0;
DOI:10.1016/S0040-4039(99)02191-7

Reference yield:

: 64134-17-4
Diethyl-α-(2,5-difluorobenzyl)-α-acetamidomalonate

: 266360-61-6
(R)-2-Amino-3-(2,5-difluoro-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 2M NaOH / methanol; H₂O / 3 h / 40 °C

2: 92 percent / p-xylene / 2 h / Heating

3: Aspergillus genus acylase; 0.2 M AcONa; 0.2 M NaOH / H₂O / 48 h / 38 °C / pH 8.0

4: 95 percent / 4 M HCl / H₂O; dioxane / 5 h / Heating

With hydrogenchloride; sodium hydroxide; Aspergillus genus acylase; sodium acetate; In 1,4-dioxane; methanol; para-xylene; water; 1: Hydrolysis / 2: Decarboxylation / 3: Deacetylation / 4: Deacetylation;
DOI:10.1016/S0040-4039(99)02191-7