2-Acetamido-3-(2,5-difluorophenyl)propanoic acid

Base Information

Chemical Name:2-Acetamido-3-(2,5-difluorophenyl)propanoic acid
CAS No.:266360-49-0
Molecular Formula:C₁₁H₁₁F₂NO₃
Molecular Weight:243.21
Hs Code.:
DSSTox Substance ID:DTXSID101297710

Synonyms:266360-49-0;2-acetamido-3-(2,5-difluorophenyl)propanoic acid;Phenylalanine, N-acetyl-2,5-difluoro-;DTXSID101297710;N-Acetyl-2,5-difluorophenylalanine;AKOS013465198;FT-0772886;F31112

Suppliers and Price of 2-Acetamido-3-(2,5-difluorophenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Acetamido-3-(2,5-difluorophenyl)propanoic acid

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:243.07069954
Heavy Atom Count:17
Complexity:298

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC(CC1=C(C=CC(=C1)F)F)C(=O)O

Technology Process of 2-Acetamido-3-(2,5-difluorophenyl)propanoic acid

There total 3 articles about 2-Acetamido-3-(2,5-difluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2-acetylamino-2-(2,5-difluoro-benzyl)-malonic acid

: 266360-49-0
2-acetylamino-3-(2,5-difluoro-phenyl)-propionic acid

Guidance literature:: In para-xylene; for 2h; Heating;
DOI:10.1016/S0040-4039(99)02191-7

Reference yield:

: 64134-17-4
Diethyl-α-(2,5-difluorobenzyl)-α-acetamidomalonate

: 266360-49-0
2-acetylamino-3-(2,5-difluoro-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2M NaOH / methanol; H₂O / 3 h / 40 °C

2: 92 percent / p-xylene / 2 h / Heating

With sodium hydroxide; In methanol; para-xylene; water; 1: Hydrolysis / 2: Decarboxylation;
DOI:10.1016/S0040-4039(99)02191-7

Reference yield:

: 85117-99-3
2-(bromomethyl)-1,4-difluorobenzene

: 266360-49-0
2-acetylamino-3-(2,5-difluoro-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaOEt / ethanol / 2 h / Heating

2: 2M NaOH / methanol; H₂O / 3 h / 40 °C

3: 92 percent / p-xylene / 2 h / Heating

With sodium hydroxide; sodium ethanolate; In methanol; ethanol; para-xylene; water; 1: Alkylation / 2: Hydrolysis / 3: Decarboxylation;
DOI:10.1016/S0040-4039(99)02191-7