(S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester

Base Information

Chemical Name:(S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester
CAS No.:1444779-16-1
Molecular Formula:C₂₃H₃₀N₂O₃
Molecular Weight:382.503
Hs Code.:

Synonyms:(S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester

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Chemical Property of (S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester

Chemical Property:

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Technology Process of (S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester

There total 6 articles about (S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 699-08-1
1-ethoxy-4-iodobenzene

: 1444779-16-1
(S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; methanol / 48 h / Reflux; Inert atmosphere

2: platinum(IV) oxide; acetic acid; hydrogen / 9 h / 20 °C / 2250.23 Torr

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane; acetonitrile / 15 h / 50 - 55 °C / Inert atmosphere

4: hydrogenchloride / isopropyl alcohol / 4 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 - 20 °C

With hydrogenchloride; platinum(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; johnphos; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; isopropyl alcohol; acetonitrile;

Reference yield:

: 1444780-57-7
(S)-1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethylamine hydrochloride

: 79-22-1
methyl chloroformate

: 1444779-16-1
(S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1444779-16-1
(S)-(1-{4-[4-(4-ethoxy-phenyl)-piperidin-1-yl]-phenyl}-ethyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; methanol / 48 h / Reflux; Inert atmosphere

2: platinum(IV) oxide; acetic acid; hydrogen / 9 h / 20 °C / 2250.23 Torr

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / 1,4-dioxane; acetonitrile / 15 h / 50 - 55 °C / Inert atmosphere

4: hydrogenchloride / isopropyl alcohol / 4 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 0 - 20 °C

With hydrogenchloride; platinum(IV) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; johnphos; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; isopropyl alcohol; acetonitrile;